课题基金 / 基金详情

GENETIC LINKAGE STUDY OF OTITIS MEDIA

GENETIC LINKAGE STUDY OF OTITIS MEDIA
中耳炎的遗传连锁研究
批准号：
6264551
负责人：
Margaretha Linnea Casselbrant
金额：
$1.63万
依托单位：
CHILDREN'S HOSP PITTSBURGH/UPMC HLTH SYS
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6264551
关键词：
alleles clinical research diagnosis design /evaluation ear disorder diagnosis epidemiology family genetics genetic disorder genetic disorder diagnosis genetic markers genome human subject linkage mapping otitis media siblings twin /multiplet

项目摘要

项目成果

Margaretha Linnea Casselbrant的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
The frequency of a single episode of otitis media (OM) is so high that a genetic predisposition is unlikely to be identified. However, the predisposition to recurrent episodes of acute otitis media (AOM) and to persistent middle ear effusion (MEE) may have a significant genetic component. The research design for this study is a sibling-pair linkage study. We have recently estimated for a twim/triplet study of OM that the susceptibility to middle ear disease has a heritability of approximately 0.72 by two years of age. This suggests that it is feasible to identify a major gene or genes contributing to susceptibility using a genome-wide screen of genetic markers in affected sibling pairs and identity-by-decent (IBD) analysis. The proposed study will recruit a sample of 200 affected sibling pairs and their available parents for the identification of susceptibility genes. The parents are being recruited to distinguish IBD for marker alleles from identify-by-state due to chance.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
ET Growth and Development: Anatomy/Function
ET Growth and Development: Anatomy/Function
ET Growth and Development: Anatomy/Function
ET Growth and Development: Anatomy/Function
海外基金