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SUBSTRATE UTILIZATION & AVAILABILITY ON EXERCISE STUDY IN HEART FAILURE

SUBSTRATE UTILIZATION & AVAILABILITY ON EXERCISE STUDY IN HEART FAILURE
基材利用率
批准号：
6117674
负责人：
DONNA M MANCINI
金额：
$2.21万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6117674
关键词：
bioenergetics carbohydrate biosynthesis carbohydrate metabolism clinical research creatine phosphate exercise fatigue glycogen heart failure human subject

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英文摘要
It has been suggested that patients with heart failure may be more dependent on intramuscular substrates(phosphocreatine & glycogen) rather than blood borne metabolic fuels for skeletal muscle energy. This study attempts to examine how the combination of low intramuscular glycogen concentration, increased rate of glycogen utilization and altered glycogen repletion effects exercise performance ventilation and muscle fatigue in heart failure patients.
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