PATHOGENESIS OF MAC DISEASE IN ADVANCED HIV 1 PATIENTS

本研究是一项横断面和纵向研究晚期hiv感染者MAC疾病的自然历史和发病机制，以及HAART（高活性抗逆转录病毒治疗）对DMAC（播散性感染鸟分枝杆菌复合体）和机会性感染相关免疫细胞群和功能的影响。本研究的目的是通过对DMAC高风险受试者进行骨髓活检和血液定量培养，确定DMAC组织感染是否发生在持续菌血症之前。此外，我们建议积极的抗逆转录病毒药物治疗由于特异性免疫缺陷而有DMAC风险的hiv感染者将以这种方式改善这些免疫功能以抵抗DMAC。

This study is a cross-sectional and longitudinal study of the natural history and pathogenesis of MAC disease in a cohort of late-stage HIV-infected subjects and the effect of HAART (Highly Active Antiretroviral Treatment) on DMAC (Disseminated infection with Mycobacterium avium complex) and opportunistic infection relevant immune cell population and functions. The purpose of this study is to determine if tissue infection with DMAC occurs prior to sustained bacteremia by obtaining bone marrow biopsies and blood for quantitative cultures from subjects at high risk for DMAC. Further, we propose that aggressive antiretroviral drug treatment of HIV-infected subjects at risk for DMAC because of specific immune deficiencies will improve these immune functions in such a manner as to resist DMAC.