To feast among the starving: facultative anaerobiosis by Mycobacterium avium.

为饥饿者提供盛宴：鸟分枝杆菌的兼性厌氧。

• 批准号: 2737328
• 金额: --
• 依托单位: University of Leicester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2737328
• 关键词: feast; among; starving; facultative; anaerobiosis

Mycobacterium avium, a slow-growing bacterium predominantly found in brackish water and soil, can cause chronic infections in animal and human populations. Understanding strategies by which bacterial pathogens adapt to the host immune response through metabolic remodelling and by employing various methods of respiration is crucial in reducing the infection rate. The method of respiration is especially important for environmental bacteria like M. avium which can survive in demanding environments. Mycobacterial genomes are highly GC-biased resulting in greater frequency of ambiguous gene attributes. These ambiguous terms including 'hypothetical', 'putative' or 'probable' have made identifying the key metabolic pathways and thus predicting respiratory mechanisms by M. avium and potentially other taxonomically related species being obscured. In this project we will investigate the ability of the non-tuberculous mycobacterium, (NTM), M. avium to survive in environmentally challenging conditions. For M. avium to proliferate in the demanding conditions, we predict that various respiratory complexes will be involved to regulate metabolism. From this research, we aim to have a better understanding of where M. avium can be found with the future purpose to reduce infections in susceptible populations.

鸟分枝杆菌是一种生长缓慢的细菌，主要存在于半咸水和土壤中，可引起动物和人类群体的慢性感染。了解细菌病原体通过代谢重塑和采用各种呼吸方法适应宿主免疫反应的策略对于降低感染率至关重要。呼吸方式对环境细菌如M.可以在苛刻的环境中生存。分枝杆菌基因组是高度GC偏向的，导致更高频率的模糊基因属性。这些模糊的术语，包括“假设”，“推定”或“可能”，使确定的关键代谢途径，从而预测呼吸机制的M。鸟类和其他潜在的分类学上相关的物种被掩盖。本课题主要研究非结核分枝杆菌（NTM）、结核分枝杆菌（M。鸟类在具有挑战性的环境条件下生存。支原体鸟类在苛刻的条件下增殖，我们预测各种呼吸复合物将参与调节代谢。通过这项研究，我们的目标是有一个更好的理解M。可以发现禽流感，未来的目的是减少易感人群的感染。