ERYTHROPOIETIN PRODUCTION BY THE MID TRIMESTER FETAL KIDNEY

妊娠中期胎儿肾脏产生的促红细胞生成素

• 批准号: 6118767
• 负责人: ROBIN OHLS
• 金额: $ 2.24万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6118767
• 关键词: clinical research; embryo /fetus; embryo /fetus hypoxia; erythropoietin; human subject; kidney function; kidney metabolism; liver metabolism

Infants born prematurely will frequently develop a hypogenerative anemia, termed the "anemia of prematurity." These infants do not increase Epo production in response to their anemia. We postulated that one of the etiologies behind the anemia of prematurity involves a delay or a defect in the premature kidney to produce Epo. It is unknown whether the human kidney can produce Epo during the mid-trimester. We propose to measure Epo message and protein production in the mid-trimester human kidney & liver under normoxic & hypoxic conditions.

早产儿常常会患上一种称为“早产儿贫血”的低生性贫血。这些婴儿不会因贫血而增加促红细胞生成素的产生。我们推测早产儿贫血背后的原因之一是早产儿肾脏产生EPO的延迟或缺陷。目前尚不清楚人类肾脏是否能在妊娠中期产生EPO。我们建议在常氧和低氧条件下测量中期人类肾脏和肝脏中EPO信息和蛋白质的产生。