ERYTHROPOIETIN PRODUCTION BY THE MID TRIMESTER FETAL KIDNEY

妊娠中期胎儿肾脏产生的促红细胞生成素

• 批准号: 6307836
• 负责人: ROBIN OHLS
• 金额: $ 2.24万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6307836
• 关键词: clinical research; embryo /fetus; embryo /fetus hypoxia; erythropoietin; human subject; kidney function; kidney metabolism; liver metabolism

Infants born prematurely will frequently develop a hypogenerative anemia, termed the "anemia of prematurity." These infants do not increase Epo production in response to their anemia. We postulated that one of the etiologies behind the anemia of prematurity involves a delay or a defect in the premature kidney to produce Epo. It is unknown whether the human kidney can produce Epo during the mid-trimester. We propose to measure Epo message and protein production in the mid-trimester human kidney & liver under normoxic & hypoxic conditions.

早产的婴儿通常会患上再生障碍性贫血， 被称为“早产儿贫血”“这些婴儿不会增加Epo 以应对他们的贫血。我们假设其中一个 早产儿贫血背后的病因涉及延迟或缺陷 产生促红细胞生成素 目前尚不清楚人类是否 肾脏在妊娠中期可以产生促红细胞生成素。 我们建议测量 人中期肾脏中的促红细胞生成素信息和蛋白质生成 常氧和缺氧条件下的肝脏。