HARVARD NATHAN SHOCK CENTER IN BASIC BIOLOGY OF AGING

为了支持衰老基础生物学的研究，哈佛医学院 学校的老龄化部门及其附属机构建议， 建立一个由国家免疫局资助的内森·休克衰老基础生物学中心。 的 该中心的目标是提供最先进的 基础设施、资源和服务，供基础科学家研究 衰老过程的分子基础和与年龄相关的 疾病 更具体地说，建议的研究资源核心是 旨在促进和进一步加速积极追求 关于衰老遗传学的假设，从分子到 有机体 例如，该中心将支持对DNA的调查， 不稳定性作为癌症和衰老的潜在原因，基因 在衰老和疾病过程中表达的变化，以及衰老和 长寿基因决定健康寿命。 提出了三个研究资源核心：（1）基因分析 突变;（2）基因转录恢复和基因发育;和（3） 转基因和遗传模型系统。 除了技术服务 和资源，这些核心还将提供有关主题的培训课程， 在分子老年学中。 此外，一个研究开发核心，将 为对老龄化感兴趣的初级教师提供完整的培训计划 研究，并鼓励其他学科的高级教师考虑 将他们的专业知识应用于老龄化问题， 核心将提供行政监督，组织讲习班和特别会议。 研讨会，促进利用核心设施，发展国际 联系网络，并寻求长期的永久资金来源。

In order to support research on basic biology of aging, Harvard Medical School's Division on Aging and its affiliated institutions propose to establish an NIA-funded Nathan Shock Basic Biology of Aging Center. The goals of this proposed Center are to provide state-of-the-art infrastructure, resources and services for basic scientists to study the molecular basis of the aging process and the development of age-associated diseases. More specifically, the research resource cores proposed are designed to facilitate and further accelerate the aggressive pursuit of hypotheses concerning the genetics of aging, from the molecule to the organism. As examples, the Center will support investigations on DNA instabilities as potential causal factors in cancer and aging, gene expression changes during aging and disease, and the role of aging and longevity genes in determining healthy lifespan. Three Research Resource cores are proposed: (1) Analysis of Gene Mutations; (2) Gene Transcript Recovery and Gene Development; and (3) Transgenetic and Genetic Model Systems. In addition to technical services and resources, these cores will also provide training courses on subjects in molecular gerontology. In addition, a Research Development Core, will provide a complete training program for junior faculty interested in aging research, and encourage senior faculty in other disciplines to consider applying their expertise to questions in aging, and a program Enrichment Core will provide administrative oversight, organize workshops and special seminars, promote utilization of Core facilities, develop an international network of contacts, and seek long-term permanent sources of funding.