Disruption of proteolytic cascades in the skin:towards halting the atopic march

破坏皮肤中的蛋白水解级联：阻止特应性病的进展

• 批准号: nhmrc : 1059410
• 负责人: A/Pr Jonathan Harris
• 金额: $ 25.91万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/disruption-proteolytic-cascades-atopic-march/454756
• 关键词: Disruption; proteolytic; cascades; skin; towards

There are over 3000 named skin disorders which range in severity from the trivial including acne, to life threatening such as skin cancer. Many skin diseases result from a lack of control over the way the skin maintains itself. Cutting the connections that hold cells together is key to balancing loss of skin cells with their continuous replacement. This project focuses on making compounds to block skin cell shedding with the longer term aim of producing novel drugs to treat skin disease.

有3000多种被命名的皮肤病，其严重程度从琐碎的粉刺到威胁生命的皮肤癌。许多皮肤病是由于缺乏对皮肤自我维持方式的控制造成的。切断将细胞连接在一起的连接是平衡皮肤细胞损失和不断更新的关键。该项目专注于制造阻止皮肤细胞脱落的化合物，长期目标是生产治疗皮肤病的新药。