International Retroviral Symposium: Assembly, Maturation and Uncoating

国际逆转录病毒研讨会：组装、成熟和脱壳

• 批准号: 10762858
• 负责人: Saveez Saffarian
• 金额: $ 2.5万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-14 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10762858
• 关键词: Acquired Immunodeficiency Syndrome; Antiviral Agents; Area; Australia; Binding; Biochemical; Biochemistry; Bioinformatics; Biophysical Process; Biophysics; Boston; Cells; Chromosomes; Collaborations; Complex; Country; Development; Discipline; Disease; Ensure; Environment; Enzymes; Europe; Exposure to; Female; Funding; Genome; Goals; HIV-1; Human; Infection; Integrase; International; International Cooperation; Life Cycle Stages; Location; Malignant Neoplasms; Membrane; Mentors; Microscopy; Nature; Nucleocapsid Proteins; Outcome; Participant; Persons; Postdoctoral Fellow; Principal Investigator; Process; Proteolytic Processing; Proteomics; RNA; RNA-Directed DNA Polymerase; Research; Research Personnel; Resolution; Retroviridae; Reverse Transcription; Role; Scientist; Students; System; Techniques; Time; Training; Translating; Underrepresented Minority; United States National Institutes of Health; Utah; Viral; Virion; Virus; Virus Assembly; broadening participation research; combat; gag-pol Fusion Proteins; human disease; male; meetings; minority scientist; next generation; novel strategies; patient engagement; programs; symposium; therapeutic target; virology; web site; young woman

ABSTRACT During the past decades, the International Retroviral Symposium has focused on identifying key interactions essential for viral assembly and maturation with a particular focus on the nucleocapsid protein and its role. The last meeting of the international retroviral symposium was held in Boston at 2019 where we emphasized the role of NC/Gag in assembly highlighting what has been significant progress in this exciting area. In the 12th International Retroviral Symposium (IRS), we aim to expand the conference focus to include uncoating, and more broadly identify molecular interactions that connect various stages of assembly, maturation and uncoating. The conference has traditionally attracted a group of approximately 100 participants from around the globe. In the 12th IRS, we expect a slightly larger pool of participants, approximately 150, based on the broader focus of the symposium and the long period of time since the 11th symposium held in August 2019. Snowbird Utah provides an idyllic location due to its secluded nature and excellent conference support facility, which maximizes participant engagement. The goal of the 12th IRS is to provide a forum and facilitate identification of fundamental biophysical, biochemical, and virological principles governing retroviruses. These principles will in turn guide development of new antivirals, potent lentiviral systems, and better understanding of the role of retroviruses in human disease, all of which are within the focus of NIH. Our invited speakers are a mix of more junior and established principal investigators, represent countries with active retroviral research and include a significant number of female researchers. The majority of NIH funding will be used to broaden the participation of younger and less represented researchers within the symposium. NIH support is critical for training the next generation as well as injecting new ideas into the field. Conference website: https://ramm2023.utah.edu/

摘要 在过去的几十年里，国际逆转录病毒研讨会的重点是确定关键的 病毒装配和成熟所必需的相互作用，特别关注核衣壳 蛋白质及其作用国际逆转录病毒研讨会的最后一次会议在波士顿举行， 2019年，我们强调了NC/Gag在装配中的作用，突出了重要性 在这个令人兴奋的领域取得了进展。在第12届国际逆转录病毒研讨会（IRS）上，我们的目标是扩大 会议的重点包括涂层，并更广泛地确定分子相互作用， 连接组装、熟化和去涂层的各个阶段。 会议传统上吸引了来自世界各地的约100名与会者。 地球仪。在第12届国税局，我们预计参与者人数会略多，约为150人， 研讨会的重点更广泛，而且自第十一届研讨会于2002年举行以来， 2019年8月。雪鸟犹他州提供了一个田园诗般的位置，由于其隐蔽的性质和优良的 会议支助设施，最大限度地提高与会者的参与度。 第12届IRS的目标是提供一个论坛，促进确定基本的生物物理， 控制逆转录病毒的生物化学和病毒学原理。这些原则将反过来指导 开发新的抗病毒药物，有效的慢病毒系统，以及更好地了解 逆转录病毒在人类疾病中的作用，所有这些都是NIH的重点。 我们邀请的演讲者是一个混合更初级和既定的主要研究者，代表 这些国家开展了积极的逆转录病毒研究，其中包括大量女性研究人员。的 NIH的大部分资金将用于扩大年轻人和代表性较低的人的参与 研讨会上的研究人员。NIH的支持对于培养下一代以及 为这个领域注入新的想法。 会议网址：https://ramm2023.utah.edu/