TRANSPLANTION ANTIGENS--EXPRESSION AND FUNCTION
移植抗原——表达和功能
基本信息
- 批准号:6373010
- 负责人:
- 金额:$ 31.2万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1992
- 资助国家:美国
- 起止时间:1992-06-01 至 2003-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (Adapted from the Investigator's abstract): The ubiquitously
expressed highly polymorphic classical class 1 MHC antigens participate in
elimination of virally infected, malignantly transformed and allogeneic
cells. In contrast very little is currently known about oligomorphic
nonclassical transplantation antigens. These beta-2m-associated molecules
resemble structurally the classical class 1 proteins but differ in patterns
and levels of expression and the type of ligands that they associate with.
The tissue-restricted class molecule that we study is the murine Qa-2
antigen encoded by the Q9 gene of C57BL/10 mice. Qa-2 can bind a diverse
array of peptides similar to class la ligands, consistent with the
assumption that it may be involved in antigen presentation to T-cells and/or
regulation of natural immunity by NK cells. Identification of Qa-2 in
immunologically-privileged tissue and its restricted tissue distribution
suggest that this molecule may have novel or altered functions compared to
the class 1 antigens. This hypothesis will be tested in the proposed
studies. The specific aims are: 1) to construct transgenic mice expressing
single-chain Qa-2 (SCQ-2) as their only biochemically abundant class 1
molecule in beta2m-deficient C57BL/6 mice; 2) to characterize in detail
tissue, cell and tumor destruction of wild type Qa-2 transcripts and
proteins and to compare it to tissue distribution of SCQa-2 molecules in the
transgenic mice; 3) to examine development of alpha/beta T-cells and T-cell
responses controlled by Qa-2 antigens in transgenic mice; 4) to test a
hypothesis that Qa-2 functions as an inhibitory or a positive recognition
target for NK receptors. The results of the studies described in this
application will permit to assess biological functions of the model tissue
specific transplantation antigen Qa-2. This information may be helpful in
the development of unrestricted peptide vaccines against pathogens and
tumors and in future design of more efficient strategies for transplantation
and suppression of autoimmune reactions.
描述(改编自研究者摘要):无所不在
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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IWONA T STROYNOWSKI其他文献
IWONA T STROYNOWSKI的其他文献
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{{ truncateString('IWONA T STROYNOWSKI', 18)}}的其他基金
CORE--TISSUE CULTURE AND MONOCLONAL ANTIBODY FACILITY
核心——组织培养和单克隆抗体设施
- 批准号:
6340683 - 财政年份:2000
- 资助金额:
$ 31.2万 - 项目类别:
CORE--TISSUE CULTURE AND MONOCLONAL ANTIBODY FACILITY
核心——组织培养和单克隆抗体设施
- 批准号:
6229706 - 财政年份:1995
- 资助金额:
$ 31.2万 - 项目类别:
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