CORE--CLINICAL INVESTIGATIONS

核心——临床研究

• 批准号: 6268026
• 负责人: STEVEN A MILES
• 金额: $ 13.86万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6268026
• 关键词: AIDS; HIV infections; Kaposi's sarcoma; biomedical facility; cell bank /registry; cerebrospinal fluid; health science research support; human tissue; pathologic process; plasma; serum; tissue resource /registry

The UCLA CFAR Clinical Investigations Core is designed to facilitate interactions between clinical HIV infection and its related malignant complications. The core utilizes the expertise of the director in the pathogenesis of Kaposi sarcoma and immune based therapy and accesses the clinical materials generated from clinical trials of patients with immune modulating agents such as interferons, interleukin-2, interleukin-4, and interleukin-12 trials. By facilitating a close interface between basic scientists and clinicians, cost effective and productive studies often result. The core provides four basic services: 1. logistical support for the scientists and basic researchers that further our understanding of the immunopathogenesis of collection of clinical specimens from patients including serum, plasma, spinal fluid and other non-malignant body fluids. 2. access to non-malignant stored clinical specimens including access to unique clinical specimens from patients on immune modulator or gene therapy trials for retrospective studies. 3. consultative support including assistance with applications to the institutional review board for prospective specimens, and 4. maintains a computerize data base of existing specimens for easy retrieval. The core currently has over 40,000 specimens available and has correlative clinical information on over 4,000 patients. The core continues to acquire over 1,000 new samples per year. In 1996, eight investigators processed or obtained 5,230 samples from the core. The core provides the bulk of its services on a re-charge basis providing users with a core facility that is the most cost effective approach for storage, processing and retrieval of stored specimens. It is hoped that by encouraging basic scientists to perform studies using clinical materials, in vitro observations can be rapidly translated into clinical trials and, ideally improved therapy for HIV. This core does not provide clinical trials support.

加州大学洛杉矶分校 CFAR 临床研究核心旨在促进 临床HIV感染与其相关恶性疾病之间的相互作用 并发症。核心利用了导演的专业知识 卡波西肉瘤的发病机制和基于免疫的治疗并获取 免疫患者临床试验产生的临床材料 调节剂，例如干扰素、白细胞介素2、白细胞介素4和 白细胞介素12试验。通过促进基本之间的紧密接口 科学家和临床医生经常进行具有成本效益且富有成效的研究 结果。核心提供四种基本服务： 1. 为科学家和基础研究人员提供后勤支持 进一步我们对收集的免疫发病机制的理解 患者的临床样本，包括血清、血浆、脊髓液和 其他非恶性体液。 2. 获取非恶性存储的临床标本，包括获取 来自接受免疫调节剂或基因治疗的患者的独特临床标本 回顾性研究的治疗试验。 3. 咨询支持，包括协助申请 未来标本的机构审查委员会，以及 4. 维护现有样本的计算机化数据库，以便于 检索。 该岩心目前有超过 40,000 个可用样本，并具有相关 超过 4,000 名患者的临床信息。核心不断获取 每年超过 1,000 个新样品。 1996 年，八名调查员处理或 从岩心中获取了 5,230 个样本。核心提供了其大部分 充值服务为用户提供核心设施 最具成本效益的存储、处理和检索方法 保存的标本。希望通过鼓励基础科学家 使用临床材料进行研究，可以进行体外观察 迅速转化为临床试验，并理想地改善了治疗 艾滋病病毒。该核心不提供临床试验支持。