Dissecting the functions of accessory subunits in mitochondrial complex I

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Mitochondria are the powerhouses of our cells that produce the chemical ATP for functions such as muscle contraction and triggering of nerves. Mitochondrial Complex I is a molecular motor that helps to make this ATP. “Mitochondrial disease” is often seen when Complex I is defective resulting in early childhood death. In this project we will study the structural importance of components of Complex I and investigate the hypothesis that they also have additional functions in mitochondria.