SEGMENTAL ALLERGEN CHALLENGE IN PATIENTS WITH MILD ASTHMA

轻度哮喘患者的局部过敏原挑战

• 批准号: 6274218
• 负责人: Mario Castro
• 金额: $ 2.24万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6274218
• 关键词: active immunization; airborne allergen; asthma; bronchoscopy; clinical research; human subject; respiratory hypersensitivity

Mild asthmatics who develop a late asthmatic response to an allergen inhalational challenge will be studied. Each subject will undergo two bronchoscopic procedures, one for instillation of allergen and diluent and one for performing the biopsies, brushings, and bronchoalveolar lavage. Equal number of subjects will undergo bronchoscopy at 6 and 24 hours post challenge.

对过敏原产生迟发性哮喘反应的轻度哮喘患者 将研究吸入性挑战。每个受试者都会经历 两种支气管镜检查，一种是过敏原滴注，另一种是 一种稀释剂和一种用于进行活组织检查、刷检和 支气管肺泡灌洗。同样数量的受试者将接受 激发后6小时和24小时的支气管镜检查。