Frontiers: University of Kansas Clinical and Translational Science Institute

前沿：堪萨斯大学临床与转化科学研究所

• 批准号: 10215281
• 负责人: Mario Castro
• 金额: $ 417.1万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-07 至 2022-07-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10215281
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Contact PD/PI: Barohn, Richard Joel OVERALL: ABSTRACT Frontiers: The Heartland Institute for Clinical and Translational Research has been a catalyst for bringing together translational science investigators and stakeholders across the KC region, and beyond. Located at the University of Kansas Medical Center (KUMC) under the leadership of Dr. Barohn, our commitment to team science and multidisciplinary collaboration reaches beyond the walls of our academic health science center and promotes collaboration among investigators from diverse disciplines across local partner academic institutions and affiliated health care institutions. The vision of Frontiers is to contribute to and lead national efforts to transform the way we do clinical and translational research (CTR), and to ensure research is more rapidly and more efficiently translated to the point of care so that it may contribute to improved health. Specifically, Frontiers aims to: 1) Engage in bi-directional collaboration with all stakeholders to develop, demonstrate, and disseminate advances across the translational science spectrum that insures inclusion and integration of complex and diverse populations and individuals across the lifespan from birth to end of life; 2) Create a sustainable translational workforce of multi-disciplinary investigators, research personnel, and community and patient stakeholders in the use of translational science tools through innovative and creative programs; and 3) Strengthen institutional and regional infrastructure to accelerate translational research. We will accomplish these aims by drawing on our considerable strengths: a) developing informatics tools for making EHR data `research ready' and implementing clinic- and community-based registries for study recruitment and other translational research applications; b) nurturing and sustaining strong patient and community engagement relationships that will support research with African American, Latino, American Indian, LGBTQ, pediatric, geriatric, rare disease, prison, and rural populations; c) offering innovative training programs for the entire CTR workforce (not just investigators), including plans for comprehensive entrepreneurship and implementation research training and creating new team science brainstorming mechanisms that will lead to multidisciplinary discovery projects and d) advancing medical devices and re-purposed drugs to patients through novel strategies developed by Frontiers' Institute for Advancing Medical Innovations (IAMI)that is nationally known for its product development translational research and high impact collaborations with industry, academia, government, and disease philanthropy partners. All Frontiers units are linked by a group of Navigators that can be accessed by Frontiers investigative teams and community partners. These plans position Frontiers to contribute to goals, and lead initiatives of the CTSA network by building on technological, computational, and health/disease knowledge to advance translational research. Project Summary/Abstract Page 274 Contact PD/PI: Barohn, Richard Joel OVERALL NARRATIVE Frontiers: The Heartland Institute for Clinical and Translational Research provides infrastructure and educational programs to develop the next generation of CTR investigative teams. As a regional organization involving two states and three universities, Frontiers is able to blend the best resources available to advance team, community and clinical translational science. This results in accelerating discoveries and research findings that may be more rapidly brought to the point of care and contribute to population health.

联系PD/PI：Barohn，Richard Joel 总体：摘要 边境：心脏地带临床和转化研究所一直是带来的催化剂 整个KC地区及其他地区的转化科学研究者和利益相关者一起。位于 在巴罗恩博士的领导下，在堪萨斯大学医学中心（KUMC）的承诺 到团队科学和多学科合作范围超出我们学术健康的墙壁 科学中心并促进来自当地各个学科的研究人员的合作 合作伙伴学术机构和附属医疗机构。边境的愿景是贡献 为了改变我们进行临床和转化研究（CTR）的方式并领导国家的努力，并 确保研究更快，更有效地转化为护理点，以便可能有助于 改善健康。具体而言，边境的目的是：1）与所有人进行双向合作 利益相关者发展，演示和传播转化科学的进步 确保复杂，多样化人群和个人的包容和整合的频谱 从出生到生命尽头的寿命； 2）创建多学科的可持续转化劳动力 调查人员，研究人员以及社区和患者利益相关者在使用翻译方面 通过创新和创意计划的科学工具； 3）加强机构和地区 基础设施加速转化研究。我们将通过利用我们的目标来实现这些目标 相当大的优势：a）开发信息学工具，以使EHR数据“准备就绪”和 实施研究招聘和其他转化研究的诊所和社区注册表 申请； b）培养和维持牢固的患者和社区参与关系 支持非裔美国人，拉丁裔，美洲印第安人，LGBTQ，小儿，老年，罕见的研究 疾病，监狱和农村人口； c）为整个CTR提供创新的培训计划 劳动力（不仅仅是调查人员），包括综合企业家精神和实施计划 研究培训和创建新的团队科学集思广益机制，将导致 多学科发现项目和d）为患者推进医疗设备和重新培养药物 通过Frontiers'Deading Medical Innovations（IAIAMI）制定的新型策略 全国以其产品开发转化研究和与高影响力的合作而闻名 工业，学术界，政府和疾病慈善合作伙伴。所有边境单元都与 边境调查团队和社区合作伙伴可以访问的一组导航员。 这些计划定位前沿，通过建立CTSA网络为目标做出贡献 关于技术，计算和健康/疾病知识，以推进转化研究。 项目摘要/摘要页面274 联系PD/PI：Barohn，Richard Joel 总体叙述 边境：心脏地带临床和转化研究所提供基础设施和 发展下一代CTR调查团队的教育计划。作为区域组织 涉及两所州和三所大学，Frontiers能够融合可用的最佳资源 团队，社区和临床转化科学。这导致了加速发现和研究 可能会更迅速地将其带到护理点并为人口健康做出贡献。