Frontiers: University of Kansas Clinical and Translational Science Institute

前沿：堪萨斯大学临床与转化科学研究所

• 批准号: 10215281
• 负责人: Mario Castro
• 金额: $ 417.1万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-07 至 2022-07-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10215281
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Contact PD/PI: Barohn, Richard Joel OVERALL: ABSTRACT Frontiers: The Heartland Institute for Clinical and Translational Research has been a catalyst for bringing together translational science investigators and stakeholders across the KC region, and beyond. Located at the University of Kansas Medical Center (KUMC) under the leadership of Dr. Barohn, our commitment to team science and multidisciplinary collaboration reaches beyond the walls of our academic health science center and promotes collaboration among investigators from diverse disciplines across local partner academic institutions and affiliated health care institutions. The vision of Frontiers is to contribute to and lead national efforts to transform the way we do clinical and translational research (CTR), and to ensure research is more rapidly and more efficiently translated to the point of care so that it may contribute to improved health. Specifically, Frontiers aims to: 1) Engage in bi-directional collaboration with all stakeholders to develop, demonstrate, and disseminate advances across the translational science spectrum that insures inclusion and integration of complex and diverse populations and individuals across the lifespan from birth to end of life; 2) Create a sustainable translational workforce of multi-disciplinary investigators, research personnel, and community and patient stakeholders in the use of translational science tools through innovative and creative programs; and 3) Strengthen institutional and regional infrastructure to accelerate translational research. We will accomplish these aims by drawing on our considerable strengths: a) developing informatics tools for making EHR data `research ready' and implementing clinic- and community-based registries for study recruitment and other translational research applications; b) nurturing and sustaining strong patient and community engagement relationships that will support research with African American, Latino, American Indian, LGBTQ, pediatric, geriatric, rare disease, prison, and rural populations; c) offering innovative training programs for the entire CTR workforce (not just investigators), including plans for comprehensive entrepreneurship and implementation research training and creating new team science brainstorming mechanisms that will lead to multidisciplinary discovery projects and d) advancing medical devices and re-purposed drugs to patients through novel strategies developed by Frontiers' Institute for Advancing Medical Innovations (IAMI)that is nationally known for its product development translational research and high impact collaborations with industry, academia, government, and disease philanthropy partners. All Frontiers units are linked by a group of Navigators that can be accessed by Frontiers investigative teams and community partners. These plans position Frontiers to contribute to goals, and lead initiatives of the CTSA network by building on technological, computational, and health/disease knowledge to advance translational research. Project Summary/Abstract Page 274 Contact PD/PI: Barohn, Richard Joel OVERALL NARRATIVE Frontiers: The Heartland Institute for Clinical and Translational Research provides infrastructure and educational programs to develop the next generation of CTR investigative teams. As a regional organization involving two states and three universities, Frontiers is able to blend the best resources available to advance team, community and clinical translational science. This results in accelerating discoveries and research findings that may be more rapidly brought to the point of care and contribute to population health.

联系人 PD/PI：Barohn、Richard Joel 总体：摘要 前沿：Heartland 临床和转化研究所一直是推动 堪萨斯城地区及其他地区的转化科学研究者和利益相关者共同努力。位于 在 Barohn 博士的领导下的堪萨斯大学医学中心 (KUMC)，我们的承诺 团队科学和多学科合作超越了我们学术健康的范围 科学中心，并促进当地不同学科的研究人员之间的合作 合作学术机构和附属医疗保健机构。 Frontiers 的愿景是贡献 领导国家努力改变我们进行临床和转化研究（CTR）的方式，并 确保研究更快速、更有效地转化为护理点，以便它可以做出贡献 改善健康状况。具体来说，Frontiers 的目标是： 1) 与所有各方进行双向合作 利益相关者开发、展示和传播转化科学的进步 确保包容和融合复杂多样的人口和个人的频谱 从出生到生命终结的寿命； 2) 创建一支可持续的多学科翻译队伍 研究者、研究人员以及社区和患者利益相关者在使用转化技术时 通过创新和创意项目的科学工具； 3) 加强机构和区域 加速转化研究的基础设施。我们将通过利用我们的 相当大的优势：a) 开发信息学工具，使 EHR 数据“为研究做好准备” 实施基于临床和社区的研究招募和其他转化研究登记 应用程序； b) 培育和维持牢固的患者和社区参与关系，这将 支持非裔美国人、拉丁裔、美洲印第安人、LGBTQ、儿科、老年、罕见的研究 疾病、监狱和农村人口； c) 为整个 CTR 提供创新的培训计划 劳动力（不仅仅是调查人员），包括全面创业和实施的计划 研究培训和创建新的团队科学集思广益机制，这将导致 多学科发现项目和 d) 向患者提供医疗设备和重新利用药物 通过前沿医学创新促进研究所 (IAMI) 制定的新颖策略， 以其产品开发转化研究和与以下机构的高影响力合作而闻名全国 工业界、学术界、政府和疾病慈善事业合作伙伴。所有 Frontiers 单位都通过一个 Frontiers 调查团队和社区合作伙伴可以访问的导航器组。 这些计划使 Frontiers 能够为目标做出贡献，并通过构建 CTSA 网络来领导 CTSA 网络的举措 技术、计算和健康/疾病知识，以推进转化研究。 项目摘要/摘要第 274 页 联系人 PD/PI：Barohn、Richard Joel 整体叙述 前沿：Heartland 临床和转化研究所提供基础设施和 培养下一代 CTR 调查团队的教育计划。作为一个区域组织 Frontiers 涉及两个州和三所大学，能够整合可用的最佳资源来推进 团队、社区和临床转化科学。这会加速发现和研究 这些发现可能会更快地送到护理点并有助于人口健康。