The effect of FAHFAs on adipocyte lipolysis and inflammation

FAHFAs 对脂肪细胞脂肪分解和炎症的影响

• 批准号: NE/T014083/1
• 负责人: Leanne Hodson
• 金额: $ 0.95万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=NE%2FT014083%2F1
• 关键词: effect; FAHFAs; adipocyte; lipolysis; inflammation

MRC:Jonathan Gamwell:MR/N013468/1The UK-Canada doctoral exchange scheme will provide the opportunity to further investigate whether a particular type of fatty acid, called fatty acid hydroxy-fatty acids (FAHFA), that are produced by the fat stores in the human body play an important role in risk of developing disease like type 2 diabetes. In diseases like type 2 diabetes, the control of how fatty acids are released from fat depots in the body fails to work properly. Additionally, there is often inflammation as a symptom of the diseases which causes cells to not function properly. In this work I will be focussing predominantly on two aspects. One is determining if FAHFAs have an effect the way fat tissue released fatty acids into the blood. The other is determining whether they have any impact of decreasing the risk of inflammation in the body. Over the course of the exchange I will learn and develop the techniques required to perform these studies.

MRC：Jonathan Gamwell：MR/N 013468/1英国-加拿大博士交换计划将提供机会进一步研究一种特定类型的脂肪酸，称为脂肪酸羟基脂肪酸（FAHFA），由人体脂肪储存产生，在发展2型糖尿病等疾病的风险中发挥重要作用。在像2型糖尿病这样的疾病中，控制脂肪酸如何从体内的脂肪库中释放的方法无法正常工作。此外，通常有炎症作为疾病的症状，导致细胞不能正常工作。在这项工作中，我将主要集中在两个方面。其中之一是确定FAHFA是否会像脂肪组织将脂肪酸释放到血液中那样产生影响。另一个是确定它们是否对降低体内炎症风险有任何影响。在交流过程中，我将学习和发展进行这些研究所需的技术。