FUNCTIONAL MRI IN AGING AND ALZHEIMER'S DISEASE

认知缺陷发生在正常衰老过程中，可以在以下情况下检测到 表现与青年受试者相比，但与年龄相关 与阿尔茨海默病患者相比，缺陷更具选择性，也不那么严重 疾病(AD)。衰老过程中认知能力下降的原因尚不清楚。 疑似阿尔茨海默病的临床诊断取决于缺陷的存在 在记忆和其他认知领域，包括注意力，语言， 空间能力、抽象推理和视觉感知。每个人 患者受损和保留功能的模式可能反映出 脑内神经病变的特殊分布。这个 本研究的目的是为了研究正常衰老和老年人的相关认知。 功能性磁共振成像(FMRI)的改变 在特定的大脑区域内发出信号。我们将使用新颖的高速列车 功能磁共振成像方法，以(A)获得关于特定的神经基质的线索 衰老和阿尔茨海默病对功能性磁功能改变的认知改变 磁共振成像(FMRI)信号在特定的大脑区域。我们会 使用新的高速功能磁共振方法(A)获得有关神经的线索 衰老和阿尔茨海默病特定认知变化的基础，(B)文件 这些变化中的个体差异，以及(C)确定 神经生理标记物可能预示着非常早期的阿尔茨海默病。为了 为了实现这些目标，我们将在5年内每年进行60次功能磁共振研究- 阿尔茨海默病患者、老年对照组和年轻对照组的年周期 研究对象。我们将检查fMRI信号和fMRI信号的相关性 三个认知领域的行为容易受到 衰老与阿尔茨海默病：长期外显记忆、视觉知觉和运动 控制力。

Cognitive deficits occur in normal aging, and can be detected when performance is compared with that of young adult subjects, but age-related deficits are more selective and less severe than those in Alzheimer's disease (AD). The reasons for cognitive decline in aging are not known. The clinical diagnosis of probable AD rests upon the presence of deficits in memory and other cognitive domains, including attention, language, spatial abilities, abstract reasoning, and visual perception. Each patient's pattern of impaired and preserved function is likely to reflect the particular distribution of neuropathological changes in the brain. The goal of the proposed research is to related cognition in normal aging and AD to alterations in the functional magnetic resonance imaging (fMRI) signal within specific cerebral regions. We shall use novel high-speed fMRI methods to (a) obtain clues about the neural substrates of specific cognitive changes in aging and AD to alterations in the functional magnetic resonance imaging (fMRI) signal within specific cerebral regions. We shall use novel high-speed fMRI methods to (a) obtain clues about the neural substrates of specific cognitive changes in aging and AD, (b) document individual differences in those changes, and (c) identify neurophysiological markers that may signal very early AD. In order to achieve these goals, we shall perform 60 fMRI studies per year over a 5- year period in subjects with AD, older control subjects, nd young control subjects. We shall examine correlations between of fMRI signal and behavior in three cognitive domains that are vulnerable to the effects of aging and AD: long-term explicit memory, visual perception, and motor control.