ANALYSIS DEVELOPMENT COMPONENT

一项对整个人类基因组进行测序的拨款工作正在进行中。 利用计算工具识别功能序列元件具有 变得越来越重要。我们的长期目标是用数学 和统计方法来确定最重要的功能元素-- 大基因组中的蛋白质编码基因及其调控元件 序列。最近，我们开发了一种新的人类外显子寻找程序，名为MZEF (PNAS 94：565-568,1997)，基于现代多元统计 模式识别技术。在拟议的人类18号染色体中 测序项目，我们计划改进和扩大我们的MZEF在一个真正的 规模化顺序生产设置与集成新方法 (特别是第一个和最后一个外显子预测方法)将在 其他资助的是张博士实验室的研究项目。我们会 与信息学核心和其他组件按顺序密切交互 以测试准确性、效率和可扩展性。发展计算机化 帮助快速注释GNOME的方法也将对以下方面至关重要 实现人类基因组计划的目标，这反过来又将有一个 对人类健康和医学产生深远影响。

A grant effort is underway to sequence the entire human genome. Identification of functional sequence elements by computational tools has become increasingly important. Our long time goal is to use mathematical and statistical methods to identify most important functional elements-- protein coding genes and their regulatory elements from a large genomic sequences. Recently, we have developed a new human exon-finder called MZEF (PNAS 94:565-568, 1997), based on a modern multivariate statistical pattern recognition technique. In the proposed human chromosome 18 sequencing project, we plan to improve and to extend our MZEF in a real large-scale sequence production setting and to integrate new methods (especially first and last exon prediction methods) to be developed under the other funded research projects in Dr. Zhang's Laboratory. We shall interact with the informatics-core and other components closedly in order to test for accuracy, efficiency and scalability. Developing computational methods to assist rapid annotation of the gnome will also be vital for achieving the goals of Human Genome Project, which in turn will have a profound impact on human health and medicine.