Dissecting the role of hedgehog signalling in chondrogenesis and skeletal disease

剖析刺猬信号在软骨形成和骨骼疾病中的作用

• 批准号: nhmrc : 569713
• 负责人: A/Pr Carol Wicking
• 金额: $ 27.25万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dissecting-role-hedgehog-skeletal-disease/95358
• 关键词: Dissecting; role; hedgehog; signalling; chondrogenesis

There are close to 400 inherited disorders that affect how the skeleton develops, as well as a range of injury and age-related skeletal defects. There is much interest in treating such abnormalities with artificial bone grown outside the body. In order to achieve this aim we must understand all of the processes involved in producing and maintaining bone within the body. We are using both mouse and cell culture models of skeletal development to increase our understanding of these processes.

有近400种遗传性疾病影响骨骼的发育，以及一系列损伤和与年龄相关的骨骼缺陷。人们对用体外生长的人造骨治疗这种畸形很感兴趣。为了实现这一目标，我们必须了解在体内产生和维持骨骼的所有过程。我们正在使用骨骼发育的小鼠和细胞培养模型来增加我们对这些过程的理解。