Regulation of hedgehog signalling through intracellular trafficking events

通过细胞内贩运事件调节刺猬信号传导

• 批准号: nhmrc : 252827
• 负责人: A/Pr Carol Wicking
• 金额: $ 14.7万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-hedgehog-signalling-trafficking-events/98947
• 关键词: Regulation; hedgehog; signalling; through; intracellular

The hedgehog signalling cascade plays a role in forming almost every organ of the body during development of an embryo. Perturbation of the function of key members of this pathway during embryonic development often results in death in utero or severe childhood abnormalities. In addition, disruption to this pathway also results in a range of cancers, most notably the extremely common skin cancer basal cell carcinoma. In this proposal we aim to investigate in detail the regulatory mechanisms which operate to ensure that this complex pathway of interacting molecules functions correctly during embryonic development. By understanding how this regulation occurs we will gain valuable insight into how disruption of this pathway results in such a range of disease, as well as into how agents which modulate this pathway may potentially act in a therapeutic setting.

在胚胎发育过程中，刺猬信号级联在人体几乎所有器官的形成中都起着重要作用。在胚胎发育过程中，这一通路关键成员的功能受到干扰，通常会导致子宫内死亡或严重的儿童畸形。此外，这种通路的破坏也会导致一系列癌症，最明显的是极其常见的皮肤癌基底细胞癌。在本提案中，我们的目标是详细研究在胚胎发育过程中确保这种相互作用分子的复杂途径正确运作的调控机制。通过了解这种调节是如何发生的，我们将获得有价值的见解，了解这一途径的破坏是如何导致这种疾病的，以及调节这一途径的药物如何在治疗环境中发挥作用。