INTEGRATIVE FUNCTIONS IN NEUROVASCULAR CONTROL--PPG

在这篇文章中，我们重点讨论了三个紧密相关的主题。 第一 解决中央调解的压力反射，检查 臂旁核的整合作用; 兴奋性氨基酸;以及脑5-羟色胺系统在肾脏疾病中的作用 和心血管调整。 第二个主题是内皮细胞-- 神经-血管相互作用与3个检查旁分泌的子项目 对压力感受器的影响和机械电机制 转导; EDRF、一氧化氮（NO）和S-亚硝基硫醇（NOF）的作用 在调节交感神经功能;和旁分泌调制血管 动脉粥样硬化模型中的张力。 第三个主题涉及反射 在选定的生理和病理状态下的自主控制， 动物压力感受性反射的个体发育和差异 交感神经控制肾脏的功能成分;和其他两个 人类的子项目，一个是关于反射神经血管控制， 等长收缩运动和自主神经控制异常机制的研究 衰老和睡眠呼吸暂停综合征 三个有效规划和建立的 核心将服务于整个计划。 我们相信这个应用程序 对A委员会的批评作出直接而全面的回应。它有 几个优点：1）它是更集中的离子神经控制， 它是我们研究的强项; 2）它汇集了几个高级 来自六个部门（医学， 神经学、解剖学、药理学、儿科学和妇产科） 多年来，它一直在一起; 3）它是更加一体化的，从 将分离的细胞应用于系统、动物模型和人类; 4）它 强调了这个群体将基本概念引入其中的独特能力 人类研究的竞技场， （5）它揭示了环境的特殊记录- tors. 我们相信，总体结果将优于 的部分。

In this request, we focus on 3 tightly related themes. The first addresses Central Mediation of the Baroreflex that examines the integrative role of parabrachial nucleus; neurotransmitter functions of excitatory amino acids; and role of the brain serotonin system in renal and cardiovascular adjustments. The second theme addresses Endothelial-- Neural-Vascular Interactions with 3 subprojects that examine paracrine influences on baroreceptors and mechanisms of mechanoelectrical transduction; role of EDRF, nitric oxide (NO), and S-nitrosothiols (NOF) in regulating sympathetic function; and paracrine modulation of vascular tone in a model of atherosclerosis. The third theme addresses Reflex Autonomic Control in Selected Physiologic and Pathologic States with two subprojects in animals on the ontogeny of baroreflex and the differential sympathetic control of functional components of the kidney; and two other subprojects in humans, one on reflex neurovascular control during isometric exercise, and one on mechanisms of abnormal autonomic control with aging and sleep apnea. Three efficiently planned and established Cores will serve the entire program. We believe this application responds directly and fully to the criticisms of Committee A. It has several strengths: 1) it is more focused ion neural control which has been the forte of our research; 2) it brings together several senior investigators with various expertise from six Departments (Medicine, Neurology, Anatomy, Pharmacology, Pediatrics and Ob-Gyn) who have worked together for many years; 3) it is much more integrative extending from work on isolated cells to systems, to animal models and to humans; 4) it highlights the unique ability of this group to bring basic concepts into the arena of human investigation in an excellent scientific interactive environment; 5) it reveals the exceptional track record of the investiga- tors. We are confident the overall outcome will be better than the sum of the parts.