EFFECTS OF VITAMIN E ON CHRONIC TNF ALPHA INDUCED PARKINSONIA LIKE ATAXIA

有越来越多的证据表明人类 暗示维生素E和其他营养衍生品的作用 抗氧化剂在延缓年龄相关性疾病进展中的作用 包括帕金森氏症和阿尔茨海默病。我们已经开发出 一种动物模型，呈现出一种类似帕金森氏症的 锥体外系运动障碍是由慢性 脑室注射炎性细胞因子TNFa 大脑的系统。因此，我们希望利用这一模式来 评估维生素E的作用及其预防或阻止 慢性阻塞性肺疾病运动功能障碍的研究进展 对TNFa的管理。努力将重点放在能力上 口服维生素E会对动物进行预处理 预防幼年大鼠帕金森样共济失调的发生 慢性肿瘤坏死因子治疗。此外，还将进行研究 以确定在TNFa期间是否给予维生素E 治疗将改善或阻止癌症的进展 幼鼠的帕金森样共济失调。

There is a growing body of evidence in humans implicating the role of vitamin E and other nutritionally derived antioxidants in arresting the progression of age-related diseases including Parkinson's and Alzheimer's diseases. We have developed an animal model that presents as a "Parkinsonian-like" form of extrapyramidal motor disorder that is produced by chronically administering the inflammatory cytokine TNFa into the ventricular system of the brain. We therefore, would like to use this model to assess the role of vitamin E and its ability to prevent or arrest the progression of motor dysfunction produced by chronic administration of TNFa. Efforts will focus on the ability of pretreatment of animals with orally administered vitamin E will prevent the onset of Parkinsonian-like ataxia in young rats prior to chronic TNFa treatment. In addition, studies will also be performed to determine whether administration of vitamin E during TNFa treatment will ameliorate of arrest the progression of Parkinsonian-like ataxia in young rats.