CLINICAL IMMUNE SURVEY OF THE LONGITUDINAL PROJECT PARTICIPANTS

工作概述：本项目使用的外周血来源于

Summary of Work: This projects utilizes peripheral blood obtained from participants in the Baltimore Longitudinal Study of Aging (BLSA) to gain insight into the biological, biochemical, and molecular mechanisms underlying age-associated changes in human immune function. A number of studies have suggested that human T lymphocytes obtained from aged individuals exhibit an altered immune response to various immunological vaccines and polyclonal stimuli both in vivo and in vitro. In comparison with immune cells obtained from younger individuals, aged leukocytes also display distinctive patterns of protein phosphorylation, cytokine synthesis and gene expression, and cell-cycle progression.