CHRONIC DIABETIC PAINFUL NEUROPATHY & CARDIOVASCULAR RISK--ALTERNATIVE APPROACH

慢性糖尿病疼痛性神经病

• 批准号: 6111015
• 负责人: MARTIN J STEVENS
• 金额: --
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6111015
• 关键词: alternative medicine; analgesia; autonomic nervous system; cardiovascular disorder; clinical research; clinical trials; coronary disorder; diabetic neuropathy; disease /disorder proneness /risk; exercise; human subject; human therapy evaluation; pain; quality of life; touch

DESCRIPTION (Adapted from the applicant's abstract): The incidence of coronary heart disease (CHD) is currently 20 percent over 65 years. Numerous data suggest that hyperglycemia may be an independent risk factor for macrovascular complications. Diabetic Painful Neuropathy (DPN) affect 5-50 percent of patients with diabetes and is exacerbated by poor glycemic control. DPN is characterized by acute functional abnormalities in nerve fibers followed by chronic nerve fiber loss and blunted nerve fiber re- generation. Symptoms include tingling and burning sensations in the calves, ankles and feet. Pharmacologic treatment of DNA and DNA include tricyclic antidepressants, which are cardiotoxic and have a low potency rate. The ADA recommends the utilization of diet and exercise as the primary means of glycemic control , and therefore of DPN. Because of the increased levels of extremity pain, patients with DPN are less likely to induce exercise as a part of their health regimen. Diabetic Autonomic Neuropathy (DAN) commonly complicates diabetes. The excess cardiac mortality in diabetic patients appears to be augmented by the presence of DAN in patients with advanced deficits in sympathetic cardiovascular innervation which may augment cardiac arrhythmogenesis. One bio-energetic modality known as Reiki is an energy manipulation technique similar to therapeutic touch, a hands on modality familiar in nursing for the relief of chronic pain as well as to accelerate healing in full thickness dermal wounds. The experimental approach is to apply Reiki to patients with DPN +/- DAN in a semi-double blind, randomized crossover study to ascertain if glycemic control and cardiac autonomic functions are improve in this patients. Outcome measures will include HBA valves. The McGill-Melzack Pain questionnaire, and a quality of life questionnaire; participants will also be tested as to their ability to tolerate exercise by a 6 minute walk test. This study will help validate whether bio-energy technique can reduce pain levels, improve glycemic control by increasing exercise tolerance and improve cardiac autonomic functions both major contribution to CHD mortality.

描述（改编自申请人摘要）： 冠心病（CHD）目前在65岁以上占20%。 大量数据表明高血糖可能是一个独立的危险因素 治疗大血管并发症糖尿病疼痛性神经病变（DPN）影响 5-50%的糖尿病患者，并因血糖水平低下而加重 控制DPN的特点是急性神经功能异常， 纤维，然后是慢性神经纤维损失和钝化的神经纤维再 一代症状包括刺痛和烧灼感， 小腿、脚踝和脚。DNA和DNA的药物治疗包括 三环类抗抑郁药，具有心脏毒性， 率ADA建议将饮食和运动作为 血糖控制的主要手段，因此DPN。因为 肢体疼痛水平增加，DPN患者不太可能 把锻炼作为健康养生一部分。糖尿病自主 神经病变（DAN）通常会使糖尿病并发症。过度的心脏 糖尿病患者的死亡率似乎因以下因素而增加： 晚期交感心血管功能障碍患者的DAN 神经支配可能增加心脏血管生成。一个生物能量 灵气是一种能量操纵技术， 治疗性触摸，一种在护理中熟悉的动手方式， 慢性疼痛以及加速愈合的全层真皮 伤口实验方法是将灵气应用于DPN患者 在一项半双盲、随机交叉研究中， 如果血糖控制和心脏自主神经功能在这方面得到改善， 患者结局指标将包括HBA阀。麦吉尔-梅尔扎克 疼痛问卷和生活质量问卷;参与者将 还可以通过步行6分钟来测试他们对运动的耐受能力 test.这项研究将有助于验证生物能源技术是否可以 减少疼痛水平，通过增加运动改善血糖控制 耐受性和改善心脏自主神经功能两大贡献 冠心病死亡率。