课题基金 / 基金详情

CORE--VECTOR PRODUCTION

CORE--VECTOR PRODUCTION
核心——矢量制作
批准号：
6110538
负责人：
Arthur Dusty Miller
金额：
$20.18万
依托单位：
FRED HUTCHINSON CANCER RESEARCH CENTER
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-09-01 至 1999-08-31
来源：
https://reporter.nih.gov/project-details/6110538
关键词：
Retroviridae adeno associated virus group biomedical facility biotechnology gene therapy transfection /expression vector

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中文摘要
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英文摘要
The overall function of the Vector Core is to provide high quality retroviral vectors and adeno-associated virus (AAV) vectors to investigatOrs of this SCOR grant. Virtually all of the projects in this SCOR proposal involve utilizing retroviral vectors as an experimental tool to introduce specific genes into hematopoietic stem cells or into different hematopoietic cell lines. The Vector Core will provide different backbone vectors and packaging cell lines as well as appropriate technical advice relating to the most efficient way to engineer high titer vectors for these different studies. The Vector Core will also provide large quantities of retroviral vectors for the baboon studies in Project 6 and will assure that these different vectors are of similar titer. For the human studies proposed in Project 7 the Vector Core will assure production of clinical grade retroviral vectors for use in the gene therapy of leukocyte adherence deficiency (LAD). Quality control assays meeting FDA and RAC requirements including assays for replication-competent virus, adventitious infectious agents, and retroviral genomic rearrangements will largely be carried out in the Vector Core facility or contracted through Microbiological Associates.
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Pilot and Feasibility Program
  • 批准号：
    7337073
  • 项目类别：
  • 资助金额：
    $15.69万
  • 财政年份：
    2007
  • 负责人：
    Arthur Dusty Miller
  • 依托单位：
    UNIVERSITY OF WASHINGTON
Administrative Core
  • 批准号：
    7499939
  • 项目类别：
  • 资助金额：
    $7.69万
  • 财政年份：
    2007
  • 负责人：
    Arthur Dusty Miller
  • 依托单位：
    UNIVERSITY OF WASHINGTON
Core--Retroviral and AAV Vector
  • 批准号：
    7337074
  • 项目类别：
  • 资助金额：
    $15.81万
  • 财政年份：
    2007
  • 负责人：
    Arthur Dusty Miller
  • 依托单位：
    UNIVERSITY OF WASHINGTON
Gene Therapy for Cystic Fibrosis Using AAV Vectors
  • 批准号：
    7154572
  • 项目类别：
  • 资助金额：
    $49.25万
  • 财政年份：
    2005
  • 负责人：
    Arthur Dusty Miller
  • 依托单位：
    UNIVERSITY OF WASHINGTON