RELOCALIZATION OF CELLULAR PKR DURING MENGO VIRUS INFECTION
RELOCALIZATION OF CELLULAR PKR DURING MENGO VIRUS INFECTION
批准号:
6117330
负责人:
ANN C. PALMENBERG
金额:
$1.13万
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-09-30 至 2000-06-30
中文摘要
我们感兴趣的是细胞对病毒感染的反应
这与宿主致病机制有何关联。作为我们的模型,我们研究
Mengo病毒感染小鼠巨噬细胞。蒙戈病毒感染是
蒙古族病毒感染的致病机制研究
老鼠是很好的特征。在蒙戈病毒感染期间,一个细胞
前哨蛋白,蛋白激酶R(PKR),从一个
胞质均匀分布于核周。PKR有
被认为在许多细胞反应中起重要作用
其他病毒感染,包括艾滋病毒-1、腺病毒和牛痘
病毒。因此,PKR可能在细胞反应中具有普遍作用。
病毒感染。为了了解蒙戈病毒感染是如何引发
PKR在感染细胞中的重新定位及其在
细胞对病毒感染的反应,我们已经创建了一个小组
减毒的芒果病毒。我们希望使用间接免疫荧光
和共聚焦显微镜来确定这些病毒是否在
在感染细胞中诱导PKR重新定位的能力。
英文摘要
We are interested in the cellular response to viral infection and
how that correlates to host pathogenesis. As our model, we study
mengo virus infection of murine macrophages. Mengo virus infection is
useful to study in that the pathogenesis of mengo virus infection in
mice is well characterized. During mengo virus infection, a cellular
sentinel protein, protein kinase R (PKR), is relocalized from a
uniform cytoplasmic distribution to a perinuclear locale. PKR has
been implicated as being important in the cellular response to many
other virus infections including, HIV-1, adenovirus, and vaccinia
virus. So, PKR may have a universal role in the cellular response to
viral infections. To understand how mengo virus infection elicits a
relocalization of PKR in infected cells and how this is important in
the cellular response to viral infection, we have created a panel of
attenuated mengo viruses. We wish to use indirect immunofluorescence
and confocal microscopy to determine if these viruses are impaired in
the ability to elicit a relocalization of PKR in infected cells.
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