NEUROBEHAVIORAL EFFECTS OF PARTIAL SLEEP DEPRIVATION

部分睡眠剥夺对神经行为的影响

• 批准号: 6274494
• 负责人: DAVID F DINGES
• 金额: $ 2.5万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-15 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6274494
• 关键词: behavioral /social science research tag; clinical research; cognition; human subject; mood disorders; neuropsychological tests; performance; psychobiology; sleep deprivation; wakefulness

This project seeks to determine how waking neurobehavioral functions (sleep propensity, cognitive performance, sleepiness, and mood) are affected by partial sleep deprivation (PSD). PSD has been identified as a serious public health problem being experienced daily by millions of people as a result of medical, psychiatric, and sleep disorders, as well as social demands (work, family, travel). Although highly prevalent, little scientific work has been done on the nightly duration of sleep and number of days of PSD that will lead to daytime sleepiness, involuntary sleep episodes, performance failures-- information that is essential to determining the level of PSD that could result in accidents (e.g., motor vehicle). In a preliminary study, we developed a protocol for studying PSD and demonstrated the sensitivity of a set of neurobehavioral measures to sleep restriction over 1 week. Utilizing this approach, a randomized control trial using independent groups was initiated to test the effecs on waking function of the types of sleep restriction most commonly experienced by people. The purpose of this study is to determine the nature of the cumulative waking changes in neurobehavioral functions engendered by restricting nocturnal sleep to 4.0 hrs, 6.0 hrs, and 8.0 hrs (control) per night for 14 consecutive nights. Following a 7-14 day period at home, during which time the subjects are monitored to ensure they have a stable sleep/wake cycle, subjects will live in the Inpatient Study Unit of the CRC for 20 consecutive days, during which time their sleep and waking neuro- behavioral functions are monitored. Following 3 baseline days of 8-10 hr sleep/night, subjects will be randomly assigned to one of the three sleep restriction conditions (4,6,8 hr/night) for the next 14 days, followed by 3 days of recovery sleep (8 hr/night). Changes in sleep polysomnograpy and waking neurobehavioral functions at different circadian phases across the 2-week period of sleep restriction are compared among the three groups.

这个项目旨在确定清醒时的神经行为功能 （睡眠倾向、认知表现、嗜睡和情绪） 部分睡眠剥夺（PSD）。 已确定私营部门司 作为一个严重的公共卫生问题，每天都有数百万人经历 由于医疗，精神病和睡眠障碍， 以及社会需求（工作、家庭、旅行）。 虽然高度 关于夜间持续时间的科学研究很少， 睡眠和PSD的天数，这将导致白天嗜睡， 无意识的睡眠发作，表现失败--这些信息 对于确定可能导致事故的PSD水平至关重要 (e.g.,机动车）。 在一项初步研究中，我们制定了一项协议， 用于研究PSD，并证明了一组 神经行为测量睡眠限制超过1周。 利用 这种方法，使用独立组的随机对照试验， 开始测试睡眠类型对觉醒功能的影响 最常见的限制。 这样做的目的 这项研究的目的是确定累积的清醒变化的性质， 限制夜间睡眠产生的神经行为功能 4.0连续14次，每晚6.0小时和8.0小时（对照组） 个晚上. 在家里呆了7-14天后， 监测受试者以确保他们具有稳定的睡眠/觉醒周期， 受试者将在CRC的住院研究单位居住20 连续几天，在此期间，他们的睡眠和清醒的神经元， 行为功能受到监控。 在8-10个基线日的3天后 小时睡眠/夜，受试者将被随机分配到三个 接下来14天的睡眠限制条件（4、6、8小时/夜）， 随后是3天的恢复睡眠（8小时/夜）。 睡眠的变化 多导睡眠图和清醒时的神经行为功能 在两周的睡眠限制期间， 在三组之间进行比较。