NEUROBEHAVIORAL EFFECTS OF PARTIAL SLEEP DEPRIVATION

这个项目试图确定清醒的神经行为功能是如何 (睡眠倾向、认知表现、困倦和情绪)是 受部分睡眠剥夺(PSD)的影响。已确定PSD 作为一个严重的公共卫生问题，数百万人每天都在经历 由于医学、精神和睡眠障碍而导致的人，如 以及社会需求(工作、家庭、旅行)。尽管高度 普遍来说，关于夜间持续时间的科学研究很少。 睡眠和PSD的天数会导致白天困倦， 不由自主的睡眠发作，表现失败--信息是 对确定可能导致事故的PSD水平至关重要 (例如，机动车辆)。在初步研究中，我们制定了一项协议 用于研究PSD并展示了一套 神经行为措施限制睡眠超过1周。利用 该方法是一项使用独立组的随机对照试验 启动测试睡眠类型对觉醒功能的影响 人们最常经历的限制。这样做的目的是 这项研究是为了确定睡眠中累积清醒变化的性质 限制夜间睡眠的神经行为功能 每晚4.0小时、6.0小时和8.0小时(对照)，连续14天 夜晚。在家里呆了7-14天，在这段时间里， 受试者被监测以确保他们有一个稳定的睡眠/清醒周期， 受试者将在儿童中心的住院学习单元生活20年 连续几天，在这段时间里，他们的睡眠和清醒的神经- 对行为功能进行监测。以下3个基准日为8-10天 HR睡眠/夜间，受试者将被随机分配到三个组中的一个 接下来14天的睡眠限制条件(4、6、8小时/晚)， 然后进行3天的恢复期睡眠(每晚8小时)。睡眠的变化 不同年龄组多眠与清醒神经行为功能的差异 在为期两周的睡眠限制期间，昼夜节律是 比较三组间的差异。

This project seeks to determine how waking neurobehavioral functions (sleep propensity, cognitive performance, sleepiness, and mood) are affected by partial sleep deprivation (PSD). PSD has been identified as a serious public health problem being experienced daily by millions of people as a result of medical, psychiatric, and sleep disorders, as well as social demands (work, family, travel). Although highly prevalent, little scientific work has been done on the nightly duration of sleep and number of days of PSD that will lead to daytime sleepiness, involuntary sleep episodes, performance failures-- information that is essential to determining the level of PSD that could result in accidents (e.g., motor vehicle). In a preliminary study, we developed a protocol for studying PSD and demonstrated the sensitivity of a set of neurobehavioral measures to sleep restriction over 1 week. Utilizing this approach, a randomized control trial using independent groups was initiated to test the effecs on waking function of the types of sleep restriction most commonly experienced by people. The purpose of this study is to determine the nature of the cumulative waking changes in neurobehavioral functions engendered by restricting nocturnal sleep to 4.0 hrs, 6.0 hrs, and 8.0 hrs (control) per night for 14 consecutive nights. Following a 7-14 day period at home, during which time the subjects are monitored to ensure they have a stable sleep/wake cycle, subjects will live in the Inpatient Study Unit of the CRC for 20 consecutive days, during which time their sleep and waking neuro- behavioral functions are monitored. Following 3 baseline days of 8-10 hr sleep/night, subjects will be randomly assigned to one of the three sleep restriction conditions (4,6,8 hr/night) for the next 14 days, followed by 3 days of recovery sleep (8 hr/night). Changes in sleep polysomnograpy and waking neurobehavioral functions at different circadian phases across the 2-week period of sleep restriction are compared among the three groups.