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MOLECULAR GENETICS OF RETINAL DEVELOPMENT AND INHERITED EYE DISEASE

MOLECULAR GENETICS OF RETINAL DEVELOPMENT AND INHERITED EYE DISEASE
视网膜发育和遗传性眼病的分子遗传学
批准号：
6274588
负责人：
ANAND SWAROOP
金额：
$2.15万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6274588
关键词：
albinism clinical research complementary DNA developmental genetics eye disorder genetic disorder genetic mapping human genetic material tag human subject molecular cloning molecular pathology nucleic acid sequence retina retinitis pigmentosa sex linked trait

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中文摘要
翻译
实验室研究的目标是了解分子机制。 视觉系统的发育和相关的遗传缺陷 天哪。我们正在使用位置克隆策略来分离基因 与视网膜炎相关的X连锁眼病的基因座 着色剂。差减cdna克隆已被用来识别视网膜 和胎儿眼睛特异的cDNA。眼睛特定的表达序列标签 正在开发用于基因组图谱绘制和识别的cDNA 候选疾病基因座。一些优先选择的基因 在视网膜中表达的基因正在被研究。
英文摘要
The goal of research in the lab is to understand the molecular mechanism of the development of visual system and associated genetic defects in man. We are using positional cloning strategies to isolate the genetic loci for X-linked eye diseases with a particular focus on Retinitis Pigmentosa. Subtraction cDNA cloning has been used to identify retina and fetal eye specific cDNAs. Expressed sequence tags for eye-specific cDNAs are being developed for genome mapping and for identifying candidate disease loci. A number of genes that are preferentially expressed in the retina are being investigated.
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