ACTG 244--CONDON 215 MUTATION IN ZVD MONOTHERAPY/MAINTENANCE THERPY

ACTG 244--ZVD 单一疗法/维持疗法中的 CONDON 215 突变

• 批准号: 2783173
• 金额: $ 2.45万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2783173
• 关键词: AIDS; AIDS therapy; CD4 molecule; DNA damage; blood cell count; clinical research; clinical trials; human subject; human therapy evaluation; nucleic acid sequence; outcomes research; reverse transcriptase inhibitors; virus cytopathogenic effect; zidovudine

To validate that alteration in codon 215 of reverse transcriptase in plasma virus precedes the increase in circulating viral burden and the decline in CD4 count which have been observed in association with clinical failure on AZT. To determine whether alternative regimens of antiretroviral agents alter the course of unculating viral burden and CD4 changes when initiated on the basis of a mutation in codon 215.

为了验证逆转录酶第215位密码子的改变 血浆病毒先于循环病毒负荷的增加和 已观察到的与临床相关的CD_4计数下降 AZT失败。以确定替代方案是否 抗逆转录病毒药物改变病毒载量和CD4的变化 在密码子215的突变基础上启动时的变化。