ACTG 244--CONDON 215 MUTATION IN ZVD MONOTHERAPY/MAINTENANCE THERPY

为了验证逆转录酶215密码子的改变， 血浆病毒先于循环病毒负荷增加，并且 CD4计数下降，这与临床 AZT失败 为了确定是否有替代方案， 抗逆转录病毒药物改变了病毒负荷和CD4 + T细胞亚群的进程， 当基于密码子215中的突变启动时发生变化。

To validate that alteration in codon 215 of reverse transcriptase in plasma virus precedes the increase in circulating viral burden and the decline in CD4 count which have been observed in association with clinical failure on AZT. To determine whether alternative regimens of antiretroviral agents alter the course of unculating viral burden and CD4 changes when initiated on the basis of a mutation in codon 215.