SUSTAINED DEVELOPMENT OF CLINICIAN RESEARCHERS

堪萨斯大学医学中心(KUMC)的持续目标之一 是为了促进生物医学研究的发展。首要目标是 --创建一个教师研究发展项目 这将使初级临床教员在NIH更具竞争力 赠款支持--与这一机构目标完全一致。这个 开发该项目的基本原理是，临床医生和研究人员是关键 致力于发展KUMC的多学科生物医学研究团队 需要对NIH的资金具有最大的竞争力。我们将完成 通过实现两个特定目标来实现应用程序的目标；(1)增强 竞争激烈的委员会成员的独立研究技能 初级临床教员通过强化指导计划 由NIH资助的资深科学家进行的研究。导师已经被选择了，而不是 不仅要有出色的研究能力，还要作为调查人员 他们致力于发展独立的临床医生-研究人员。 强调与炎症相关的研究，以增加临床 向KUMC杰出的基础科学家致敬的研究人员 他们已经在这个地区工作了。专注于这一领域也确保了 炎症集团，KUMC的一个合作联盟超过 40名对以下领域有研究和临床兴趣的成功研究人员 炎症和自身免疫，可以包括在发育中 程序。例如，内部咨询委员会将来自于 组织。四位临床研究人员的研究项目， 旨在为NIH的使用提供强有力的初步数据 授权应用，包括：内毒素诱导的炎症介质 感染性休克；吸烟对细胞因子产生机制的影响； 2/neu、肿瘤坏死因子-α与卵巢癌耐药 胚泡着床中的炎性介质。AIM(2)将延长 通过强调初级临床医生的网络发展计划- 拥有KUMC外部资深科学家的研究人员，以及购买 将指导扩展到辅助研究技能，如写作和 我是。用于实现目标2的手段将是 概念性/协作性工作-与知名外部人员组织的会议 为每位临床医生-研究员指定的顾问，每位医生的出席情况 在两个国内/国际研究会议上担任临床医生和研究员 每年；以及每年在外部高级科学家的 实验室学习新的研究技能和方法。格兰特--和 手稿写作技能，以及口头演示，将是 受到了广泛的批评。在拟议的三年结束时 计划，我们期望该计划的四名临床医生每人- 研究人员要么由美国国立卫生研究院资助，要么拥有一个有竞争力的美国国立卫生研究院 批准申请待定。我们还预计这台样机 计划将成为KUMC主动接近 未来其临床研究人员的发展方向。考虑到这些 预期，塔赫提出的IDEA计划极有可能 对我们机构的研究产生深远而持久的影响 环境。

One of the ongoing goals of the University of Kansas medical Center (KUMC) is to foster the development of biomedical research. The primary objective of this application -- to create a faculty research development program that will make junior clinical faculty members more competitive for NIH grant support -- is fully concordant with this institutional goal. The rationale for developing the program is that clinician-researchers are key to the development of multidisciplinary biomedical research teams that KUMC needs to be maximally competitive for NIH funding. We will accomplish the application's objectives by accomplishing two specific aims; (1) enhance the independent research skills of competitively selected members of the junior clinical faculty through an intensive program of mentoring in research by senior, NIH-funded scientists. Mentors have been chosen, not only to have outstanding research capabilities, but also as investigators who are committed to the development of independent clinician-researchers. Inflammation-related research is emphasized in order to add clinical researchers to the critical mass of outstanding basic scientists at KUMC who are already working in the area. Focusing on this area also ensures that the inflammation Group, a cooperative coalition at KUMC of more than 40 successful investigators with research and clinical interests in inflammation and autoimmunity, can be included in the developmental program. For example, the internal Advisory Committee will come from this organization. The research projects of the four clinician-researchers, which are designed to provide strong preliminary data for use in an NIH grant application, include: Endotoxin-Induced Inflammatory Mediators in Septic Shock; Effect of Smoking on Mechanisms of Cytokine Production; HER- 2/neu, TNF-alpha, and Drug Resistance in Ovarian Carcinoma; and Role of Inflammatory Mediators in Blastocyst Implantation. Aim (2) will extend the developmental program by emphasizing networking of the junior clinician- researchers with senior scientists who are external to KUMC, as well as buy extending mentoring to ancillary research skills, such as writing and speaking. The means used to accomplish aim 2 will be conceptual/collaborative work-sessions organized with prominent external advisors appointed for each clinician-researcher, attendance of each clinician-researcher at two national/international research meetings annually; and a period spent each year in an external senior scientist's laboratory learning new research skills and approaches. Grant- and manuscript-writing skills, as well as spoken presentations, will be critiqued extensively. At the conclusion of the proposed three year program, it is our expectation that each of the program's four clinician- researchers will either be funded by NIH, or will have a competitive NIH grant application pending. We additionally expect that this prototype program will become the way that KUMC proactively approaches the development of its clinician-researchers in the future. Given these expectations, it is highly probable that tahe proposed IDeA program will have a profound and lasting impact on our institutions's research environment.