TRAUMA AND ORGAN FAILURE--ROLE OF LOCAL LPS BINDING PROTEIN

创伤和器官衰竭——局部 LPS 结合蛋白的作用

• 批准号: 6274747
• 负责人: STEWART C WANG
• 金额: $ 2.15万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6274747
• 关键词: binding proteins; computer assisted sequence analysis; genetic promoter element; immunity; injury; laboratory rat; lipopolysaccharides; molecular cloning; multiple organ failure; nucleic acid sequence; trauma

We have demonstrated that lipopolysaccharide protein (LBP) is produced at extrahepatic sites. We are investigating whether this locally- produced LBP affects local immune responses to trauma and injury. As part of these studies, we will be cloning the promoter for the rat LBP gene and require DNA sequence analysis capabilities.

我们已经证明了脂多糖蛋白(LBP)的产生 在肝外部位。我们正在调查这件事是否在当地- 产生的LBP会影响局部对创伤和损伤的免疫反应。AS 作为这些研究的一部分，我们将克隆大鼠LBP的启动子 基因和要求的DNA序列分析能力。