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FEASIBILITY OF ORAL INSULIN THERAPY TO DELAY BETA CELL DESTRUCTION

FEASIBILITY OF ORAL INSULIN THERAPY TO DELAY BETA CELL DESTRUCTION
口服胰岛素治疗延迟 β 细胞破坏的可行性
批准号：
6274875
负责人：
ADINA ZEIDLER
金额：
$3.67万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6274875
关键词：
child (0-11) clinical research cytotoxicity diabetes mellitus therapy drug tolerance hormone therapy human subject human therapy evaluation immunosuppression insulin insulin dependent diabetes mellitus oral administration outcomes research pancreatic islets pediatric pharmacology

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中文摘要
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英文摘要
The hypothesis to be tested is that the daily ingestion of oral insulin into newly diagnosed children and adults with IDD will abrogate the autoimmune process (oral tolerance) underlying beta cell destruction either through insulin specific and/or islet cell antigen non-specific ("bystander") immunological suppression and thus preserve endogenous insulin secretion.
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会议论文
DIABETES PREVENTION TRIAL--TYPE I DIABETES
GENETICS OF IDDM IN MEXICAN AMERICAN FAMILIES
FEASIBILITY OF ORAL INSULIN THERAPY TO DELAY BETA CELL DESTRUCTION
DIABETES PREVENTION TRIAL--TYPE I DIABETES
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