STRUCTURE AND FUNCTION OF DROSOPHILA GENES RELATED TO CUT

果蝇切割相关基因的结构和功能

• 批准号: 6274683
• 负责人: ROLF BODMER
• 金额: $ 2.15万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6274683
• 关键词: Drosophilidae; arthropod genetics; gene expression; gene targeting; genetically modified animals; homeobox genes; laboratory mouse; structural genes

The cut gene in the fly distinguishes between two different types of sensory organ identities and has, therefore, been considered as a homeotic selector gene. We would like to find out if, in vertebrates, genes structurally related to cut exist and if such genes also have a selector gene function. We plan to ask these questions by using transgenic and gene knockout technology in mice.

果蝇中的切割基因区分了两种不同类型的 感觉器官的身份，因此，被认为是一个 同源异型选择基因 我们想知道在脊椎动物中， 存在结构上与cut相关的基因，并且如果这些基因也具有 选择基因功能 我们计划通过使用 转基因和基因敲除技术。