DEMOGRAPHY CORE

根据队列寿命表对寿命、存活率和死亡率的估计提供了人口老龄化的标准指标。当在确定的时期、条件和适当的同基因对照下进行估计时，实验队列的生命表被用来推断基因对寿命和年龄相关性死亡率的影响。在这一核心中，我们将提供一个项目范围内的统一平台，利用我们完善、高效的人口统计笼子系统，系统地收集和分析生命表。该核心还将生成跨越各个项目所针对的各种候选基因的同等基因线，以及 为我们的基因筛选维护一个共享突变系的单一来源。通过在单一环境中测试所有感兴趣的基因类型的生命表，这一核心提供了一个统一的背景，以便在功能老化的各个领域之间就它们如何影响人口老龄化的方面进行直接比较。

Estimates of lifespan, survival and mortality from cohort life tables provide the standard metrics of demographic aging. When estimated within defined periods, conditions and with appropriate co-isogenic controls, life tables of experimental cohorts are used to infer the effect of genes upon life span and agedependent mortality. In this core we shall provide a program-wide, uniform platform to systematically collect and analyze life tables using our well established, efficient 'demography cage' system. The core will also generate co-isogenic lines across the various candidate genes targeted by the individual projects, and maintain a single source of shared mutant lines for our genetic screens. By testing life tables of all genotypes of interest in a single environment this core provides a unifying background to make direct comparisons among the domains of functional aging in terms of how they affect demographic aging.