DEMOGRAPHY CORE

人口核心

• 批准号: 8377002
• 负责人: ROLF BODMER
• 金额: $ 14.33万
• 依托单位: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8377002
• 关键词: Accounting; Address; Affect; Aging; Animals; Benchmarking; Candidate Disease Gene; Consultations; Critiques; Data; Demographic Aging; Demography; Diet; Drosophila genus; Educational process of instructing; Environment; Gene Targeting; Genes; Genetic Screening; Genotype; Gerontology; Hand; Human; Humidity; Individual; Laboratories; Left; Life Table Analyses; Life Tables; Longevity; Measures; Methods; Metric; Research; Sample Size; Services; Source; System; Testing; Variant; cohort; design; experience; experimental analysis; genetic analysis; hazard; innovation; interest; mortality; mutant; programs; research study; senescence; skills; statistics

Estimates of lifespan, survival and mortality from cohort life tables provide the standard metrics of demographic aging. When estimated within defined periods, conditions and with appropriate co-isogenic controls, life tables of experimental cohorts are used to infer the effect of genes upon life span and agedependent mortality. In this core we shall provide a program-wide, uniform platform to systematically collect and analyze life tables using our well established, efficient 'demography cage' system. The core will also generate co-isogenic lines across the various candidate genes targeted by the individual projects, and maintain a single source of shared mutant lines for our genetic screens. By testing life tables of all genotypes of interest in a single environment this core provides a unifying background to make direct comparisons among the domains of functional aging in terms of how they affect demographic aging.

队列生命表对寿命、生存率和死亡率的估计提供了人口老龄化的标准指标。当在规定的时期、条件和适当的同基因对照下进行估计时，实验队列的生命表可用于推断基因对寿命和年龄依赖性死亡率的影响。在此核心中，我们将提供一个项目范围内的统一平台，使用我们完善的、高效的“人口统计笼”系统来系统地收集和分析生命表。该核心还将在各个项目针对的各种候选基因中生成共等基因系，并且 为我们的遗传筛选维护共享突变系的单一来源。通过在单一环境中测试所有感兴趣基因型的生命表，该核心提供了一个统一的背景，可以在功能老化领域之间就它们如何影响人口老龄化进行直接比较。