DEMOGRAPHY CORE

根据队列寿命表估计的寿命、存活率和死亡率提供了人口老龄化的标准指标。当估计在规定的时期内，条件和适当的共同基因控制，实验队列的生命表被用来推断基因对寿命和年龄依赖性死亡率的影响。在这个核心中，我们将提供一个全项目的统一平台，使用我们完善的、有效的“人口笼”系统来系统地收集和分析生命表。该核心还将在各个项目针对的各种候选基因中产生共等基因系， 为我们的基因筛选保持一个共享突变株系的单一来源。通过在单一环境中测试所有感兴趣的基因型的生命表，该核心提供了一个统一的背景，以便在功能性衰老的领域之间就它们如何影响人口老龄化进行直接比较。

Estimates of lifespan, survival and mortality from cohort life tables provide the standard metrics of demographic aging. When estimated within defined periods, conditions and with appropriate co-isogenic controls, life tables of experimental cohorts are used to infer the effect of genes upon life span and agedependent mortality. In this core we shall provide a program-wide, uniform platform to systematically collect and analyze life tables using our well established, efficient 'demography cage' system. The core will also generate co-isogenic lines across the various candidate genes targeted by the individual projects, and maintain a single source of shared mutant lines for our genetic screens. By testing life tables of all genotypes of interest in a single environment this core provides a unifying background to make direct comparisons among the domains of functional aging in terms of how they affect demographic aging.