DEMOGRAPHY CORE

从队列生命表中估计的寿命、生存率和死亡率提供了人口老龄化的标准指标。当在确定的时期、条件和适当的共等基因控制下进行估计时，使用实验队列的生命表来推断基因对寿命和年龄相关死亡率的影响。在这个核心，我们将提供一个项目范围内的，统一的平台，系统地收集和分析生命表，使用我们完善的，高效的“人口笼子”系统。该核心还将在各个项目针对的各种候选基因之间产生共等基因系

Estimates of lifespan, survival and mortality from cohort life tables provide the standard metrics of demographic aging. When estimated within defined periods, conditions and with appropriate co-isogenic controls, life tables of experimental cohorts are used to infer the effect of genes upon life span and agedependent mortality. In this core we shall provide a program-wide, uniform platform to systematically collect and analyze life tables using our well established, efficient 'demography cage' system. The core will also generate co-isogenic lines across the various candidate genes targeted by the individual projects, and maintain a single source of shared mutant lines for our genetic screens. By testing life tables of all genotypes of interest in a single environment this core provides a unifying background to make direct comparisons among the domains of functional aging in terms of how they affect demographic aging.