DEMOGRAPHY CORE

人口核心

• 批准号: 8377002
• 负责人: ROLF BODMER
• 金额: $ 14.33万
• 依托单位: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8377002
• 关键词: Accounting; Address; Affect; Aging; Animals; Benchmarking; Candidate Disease Gene; Consultations; Critiques; Data; Demographic Aging; Demography; Diet; Drosophila genus; Educational process of instructing; Environment; Gene Targeting; Genes; Genetic Screening; Genotype; Gerontology; Hand; Human; Humidity; Individual; Laboratories; Left; Life Table Analyses; Life Tables; Longevity; Measures; Methods; Metric; Research; Sample Size; Services; Source; System; Testing; Variant; cohort; design; experience; experimental analysis; genetic analysis; hazard; innovation; interest; mortality; mutant; programs; research study; senescence; skills; statistics

Estimates of lifespan, survival and mortality from cohort life tables provide the standard metrics of demographic aging. When estimated within defined periods, conditions and with appropriate co-isogenic controls, life tables of experimental cohorts are used to infer the effect of genes upon life span and agedependent mortality. In this core we shall provide a program-wide, uniform platform to systematically collect and analyze life tables using our well established, efficient 'demography cage' system. The core will also generate co-isogenic lines across the various candidate genes targeted by the individual projects, and maintain a single source of shared mutant lines for our genetic screens. By testing life tables of all genotypes of interest in a single environment this core provides a unifying background to make direct comparisons among the domains of functional aging in terms of how they affect demographic aging.

从队列生命表中估计的寿命、生存率和死亡率提供了人口老龄化的标准指标。当在确定的时期、条件和适当的共等基因控制下进行估计时，使用实验队列的生命表来推断基因对寿命和年龄相关死亡率的影响。在这个核心，我们将提供一个项目范围内的，统一的平台，系统地收集和分析生命表，使用我们完善的，高效的“人口笼子”系统。该核心还将在各个项目针对的各种候选基因之间产生共等基因系