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IMMUNOTHERAPY OF MALIGNACY BY IN VIVO GENE TRANSFER INTO TUMORS

IMMUNOTHERAPY OF MALIGNACY BY IN VIVO GENE TRANSFER INTO TUMORS
通过体内基因转移至肿瘤来免疫治疗恶性肿瘤
批准号：
6274616
负责人：
ALFRED E CHANG
金额：
$2.15万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6274616
关键词：
DNA clinical research clinical trial phase I gene therapy histocompatibility antigens human subject human therapy evaluation liposomes major histocompatibility complex neoplasm /cancer immunotherapy transfection /expression vector

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中文摘要
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英文摘要
Patients with advanced cancer will be treated by delivery of a DNA/liposome complex into the tumor through catheter delivery or direct injection. DNA encoding an HLA-B7 histocompatibility antigen and the gene for beta-2 microglobulin in a eukaryotic expression vector will be used. This is a phase I trial designed to assess safety of this gene therapy approach.
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会议论文
IMMUNOLOGICAL MONITORING
RESEARCH TRAINING IN TRANSLATIONAL TUMOR IMMUNOLOGY
IMMUNE RESPONSES INDUCED BY GENE TRANSFER
T CELL ACTIVATION FOR CANCER IMMUNOTHERAPY
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