ANALYSIS OF FAMILIES WITH INHERITED CRANIOFACIAL AND INNER EAR MALFORMATIONS

遗传性颅面和内耳畸形家族的分析

• 批准号: 6274634
• 负责人: Andrew J Griffith
• 金额: $ 2.15万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6274634
• 关键词: clinical research; congenital ear disorder; congenital oral /facial /cranial defect; family genetics; gene mutation; human subject; laboratory mouse

This study seeks to identify inherited human disorders of inner ear and/or craniofacial development caused by mutations of the human homolog of the mouse Twirler gene causing craniofacial and inner ear malformations in affected animals.

这项研究旨在识别遗传性人类内耳疾病 和/或由人类同系物突变引起的颅面发育 导致颅面和内耳的小鼠 Twirler 基因 受影响动物的畸形。