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Molecular Genetic Analysis of the Mouse Twirler Mutation

Molecular Genetic Analysis of the Mouse Twirler Mutation
小鼠 Twirler 突变的分子遗传学分析
批准号：
6431993
负责人：
Andrew J Griffith
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6431993
关键词：
genetic mapping laboratory mouse labyrinth molecular genetics

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英文摘要
The mouse Twirler mutation on chromosome 18 causes circling behavior due to abnormal inner ear development in Tw/+ heterozygotes, and cleft lip and palate in Tw/Tw homozgyotes. We are genetically mapping Tw on chromosome 18 using a large mapping backcross. We plan to attempt to identify the Tw gene by positional cloning or positional candidate gene approaches. Our current mapping data places Twirler approximately 1 centimorgan from the centromere of mouse chromosome 18.
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