TRACER 3D cultures to unravel the role of myoepithelial cells in breast cancer progression

TRACER 3D 培养揭示肌上皮细胞在乳腺癌进展中的作用

• 批准号: NE/V021028/1
• 负责人: Richard Grose
• 金额: $ 1.7万
• 依托单位: Queen Mary University of London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=NE%2FV021028%2F1
• 关键词: TRACER; 3D; cultures; unravel; role

MRC : Mohammad Reza Roozitalab: MR/N014308/1Cancer cells can be expanded and studied alone outside of the body in two-dimensional plastic dishes. These simplistic conditions lack the genetic variation and complex signals found in human tumours that tell cancer cells to grow uncontrollably and spread throughout the body. To effectively identify the signals that fuel breast cancer spread and develop clinical therapies to stop them, scientists require new ways of growing cancer cells outside of the body. The student will receive world-class training in Canada to build innovative three-dimensional 'mini tumour models' that better mimic the native environment of cancer cells. By combining different cell types, they will investigate how cancer cells communicate and corrupt non-cancerous cells including neighbouring immune cells, to fuel their own growth. Using newly gained expertise, the student will establish this unique method of fabricating and analysing 'mini-tumours' back in the UK to sustain and develop new long-term collaborations in Canada.

MRC：Mohammad Reza Roozitalab：MR/N 014308/1癌细胞可以在体外二维塑料培养皿中单独扩增和研究。这些简单的条件缺乏人类肿瘤中发现的遗传变异和复杂信号，这些信号告诉癌细胞不受控制地生长并扩散到全身。为了有效地识别促进乳腺癌扩散的信号并开发临床治疗方法来阻止它们，科学家们需要在体外培养癌细胞的新方法。学生将在加拿大接受世界一流的培训，以建立创新的三维“微型肿瘤模型”，更好地模拟癌细胞的原生环境。通过结合不同的细胞类型，他们将研究癌细胞如何沟通和破坏包括邻近免疫细胞在内的非癌细胞，以促进自身的生长。利用新获得的专业知识，学生将在英国建立这种独特的制造和分析“微型肿瘤”的方法，以维持和发展加拿大新的长期合作。

项目成果

An off-the-shelf multi-well scaffold-supported platform for tumour organoid-based tissues.

一个现成的多孔支架支持的平台，用于基于肿瘤类器官的组织。

• DOI: 10.1016/j.biomaterials.2022.121883
• 发表时间: 2022
• 期刊: Biomaterials
• 影响因子: 14
• 作者: Li NT