富含脂肪的早餐后赛尼可对 LPL 和 HTGL 的影响-猫眼课题宝

富含脂肪的早餐后赛尼可对 LPL 和 HTGL 的影响

批准号：

2783967

负责人：

金额：

$3.28万

依托单位：

UNIVERSITY OF COLORADO DENVER

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/2783967

关键词：

clinical research clinical trials dietary lipid drug metabolism drug screening /evaluation endocrine disorder chemotherapy enzyme activity enzyme inhibitors human subject human therapy evaluation lipoprotein lipase nutrition related tag pancreas enzyme triacylglycerol lipase weight control agent

中文摘要

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英文摘要

Xenical (orlistat) is a new anti-obesity drug which limits fat absorption by the inhibition of pancreatic lipase (PL) activity. Xenical may inhibit systemic plasma lipases as well as gastrointestinal lipases. The effect or lack thereof that Xenical or its metabolites have on lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL) activity during the time triglycerides appear in the circulation after eating needs to be established. Therefore, the effects of Xenical and its metabolites on postprandial pre-and postheparin LPL and HTGL activities and on postprandial plasma lipoprotein concentrations were examined in this clinical trial.

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海外基金

EFFECTS OF XENICAL ON LPL AND HTGL FOLLOWING A FAT RICH BREAKFAST

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