EFFECTS OF INHALED NITRIC OXIDE(NO) ON OXIDANT INJURY IN INFANTS W/RESP. FAILURE

吸入一氧化氮（INO）是一种令人兴奋的新疗法， 严重肺部疾病的新生儿，在大规模的 临床研究。一氧化氮（NO）是一种分子， 只作为一种环境污染物存在于汽车尾气和香烟中 抽烟然而，已经发现NO扩张血管， 肺使受伤的肺部能够更多地输送氧气和二氧化碳 有效地其在新生儿中使用的长期影响是 不知道。 该项目建议调查INO疗法是否会导致证据 类似于长时间暴露在 氧气这种类型的伤害的证据将通过以下方式来寻找： 对接受NO和氧气的婴儿血液的实验室研究， 只有氧气。这些结果也将与来自 正常的婴儿这些样本是从重症监护室的婴儿中抽取的。 护理托儿所在帕卡德儿童医院和研究是 在菲利斯登内里的实验室里加工的 初步结果表明氧化损伤明显增加 与接受NO的婴儿相比， 给接受高浓度氧气的婴儿虽然没有出现 是严重呼吸衰竭的重要治疗方法，长期使用 可能与不良后果有关，如慢性肺 疾病 该项目有能力通过增加儿童的 了解INO治疗的毒性。如果显著 如果INO治疗发现异常，则该信息将 这对指导新生儿进一步使用这种疗法至关重要。

Inhaled nitric oxide (INO) is an exciting new therapy being used in newborns with severe lung disease which has shown great success in large clinical studies. Nitric oxide (NO) was a molecule previously known only as an environmental pollutant found in car exhaust and cigarette smoke. However, NO has been found to dilate the blood vessels in the lung enabling injured lungs to transfer oxygen and carbon dioxide more effectively. The long term effects of its use in newborn infants are not known. The project proposes to investigate whether INO therapy causes evidence of injury similar to that which is seen with prolonged exposure to oxygen. Evidence of this type of injury will be sought by doing laboratory studies on the blood of infants receiving NO and oxgyen and oxygen alone. These results will also be compared to samples from normal infants. The samples are drawn from infants in the Intensive Care Nursery at Packard Children's Hospital and the studies are processed in Phyllis Dennery's laboratory. Preliminary results demonstrate a definite increase in oxidative injury and depleted antioxidant defenses in infants receiving NO when compared to infants receiving high oxygen concentrations. While NO appears to be an important therapy for severe respiratory failure, prolonged use may be associated with adverse consequences such as chronic lung disease. This project has the ability to benefit children by increasing the knowledge about the toxicities of INO therapy. If signficant abnormalities are found with INO therapy, this information will be critical to guide further use of this therapy in newborns.