ALPRAZOLAM INDUCED CHANGES IN CEREBRAL BLOOD VOLUME

目的：本研究比较了不同性别、不同文化程度的 安非拉唑仑与局部脑血变化的客观标志 快速磁共振成像(FMRI)测量的体积(RCBV)和 验证了右额叶rCBV下降的假设 右侧尾状核与所报道的欣快感程度成反比 由受试者决定。 方法：这是一种双盲、安慰剂对照的方案，将 比较18-24岁酗酒者成年子女的反应 (ACOA)和正常对照对自己和对彼此。 结果：在我们的研究中，7例ACoA患者的左额叶rCBV改变与 与药物反应的大小成反比(r=-0.89，p&lt；0.007)。 结论：fMRI可用于脑功能损害的检测。 与受试者的主观体验相关。

Objective: This study compares the subjective feelings induced by aprazolam with an objective marker, changes in regional cerebral blood volume (rCBV) as measured by fast Magnetic Resonance Imaging (fMRI) and tests the hypothesis that the decrease in rCBV in the right frontal lobe and right caudate is inversely related to the degree of euphoria reported by the subjects. Method: This is a double blind, placebo controlled protocol which will compare the response of 18-24 year old adult children of alcoholics (ACOAs) and normal controls to themselves and to each other. Results: In our study of 7 ACOAs the left frontal rCBV change correlated inversely with the magnitude of the drug response (r=-0.89, p<0.007). Conclusion: fMRI can be used to detect chugs in brain function which correlate with the subjective experiences of the subjects.