ALPRAZOLAM INDUCED CHANGES IN CEREBRAL BLOOD VOLUME

阿普唑仑引起脑血容量的变化

• 批准号: 6275685
• 负责人: CHRIS C STREETER
• 金额: $ 4.05万
• 依托单位: TUFTS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6275685
• 关键词: alprazolam; blood volume; cardiovascular pharmacology; clinical research; functional magnetic resonance imaging; human subject; neuropharmacology; psychopharmacology; young adult human (21-34)

Objective: This study compares the subjective feelings induced by aprazolam with an objective marker, changes in regional cerebral blood volume (rCBV) as measured by fast Magnetic Resonance Imaging (fMRI) and tests the hypothesis that the decrease in rCBV in the right frontal lobe and right caudate is inversely related to the degree of euphoria reported by the subjects. Method: This is a double blind, placebo controlled protocol which will compare the response of 18-24 year old adult children of alcoholics (ACOAs) and normal controls to themselves and to each other. Results: In our study of 7 ACOAs the left frontal rCBV change correlated inversely with the magnitude of the drug response (r=-0.89, p<0.007). Conclusion: fMRI can be used to detect chugs in brain function which correlate with the subjective experiences of the subjects.

目的：本研究比较