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FFA METABOLISM BY SKELETAL MUSCLE IN NIDDM--REGULATION BY SHORT TERM CALORIES

FFA METABOLISM BY SKELETAL MUSCLE IN NIDDM--REGULATION BY SHORT TERM CALORIES
NIDDM 中骨骼肌的 FFA 代谢——短期卡路里的调节
批准号：
6275832
负责人：
David E Kelley
金额：
$1.91万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6275832
关键词：
biopsy caloric dietary content clinical research clinical trials exercise fatty acid metabolism glucose metabolism human subject lipid metabolism malonyl coA muscle metabolism noninsulin dependent diabetes mellitus nutrition related tag striated muscles

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中文摘要
翻译
这项研究将调查这样一种假设，即骨骼肌脂肪酸 NIDDM患者运动过程中的氧化会发生改变。除了研究之外 在NIDDM中利用运动，将被用于评估血糖和血脂 氧化和经皮肌活检将用于测定CPT I 活性和丙二酰辅酶A含量。这些测量将允许 运动肌肉对葡萄糖和游离脂肪酸相对利用率的评价 正常受试者和糖尿病患者。
英文摘要
This study will investigate the hypothesis that skeletal muscle fatty acid oxidation during exercise is altered in NIDDM. In addition to studies utilizing exercise in NIDDM, will be used to assess glucose and lipid oxidation, and percutaneous muscle biopsy will be obtained to assay CPT I activity and malonyl CoA content. These measurements will permit an evaluation of relative use of glucose and FFA by exercising muscle in normal subjects and diabetics.
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