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FFA METABOLISM BY SKELETAL MUSCLE IN NIDDM--REGULATION BY SHORT TERM CALORIES

FFA METABOLISM BY SKELETAL MUSCLE IN NIDDM--REGULATION BY SHORT TERM CALORIES
NIDDM 中骨骼肌的 FFA 代谢——短期卡路里的调节
批准号：
6275832
负责人：
David E Kelley
金额：
$1.91万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6275832
关键词：
biopsy caloric dietary content clinical research clinical trials exercise fatty acid metabolism glucose metabolism human subject lipid metabolism malonyl coA muscle metabolism noninsulin dependent diabetes mellitus nutrition related tag striated muscles

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英文摘要
This study will investigate the hypothesis that skeletal muscle fatty acid oxidation during exercise is altered in NIDDM. In addition to studies utilizing exercise in NIDDM, will be used to assess glucose and lipid oxidation, and percutaneous muscle biopsy will be obtained to assay CPT I activity and malonyl CoA content. These measurements will permit an evaluation of relative use of glucose and FFA by exercising muscle in normal subjects and diabetics.
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