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EFFECT OF FOOD ON ABSORPTION OF ORAL 5-FU/776C85

EFFECT OF FOOD ON ABSORPTION OF ORAL 5-FU/776C85
食物对口服 5-FU/776C85 吸收的影响
批准号：
6275749
负责人：
Sridhar Mani
金额：
$3.82万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6275749
关键词：
5 fluorouridine clinical research drug administration rate /duration food gastrointestinal drug absorption human subject human therapy evaluation neoplasm /cancer neoplasm /cancer chemotherapy oral administration pharmacokinetics

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英文摘要
To evaluate the impact of food on absorption of oral 5-FU and 776C85, 12 patients with advanced cancer will be randomly assigned to receive 5-FU + 776C85 tablets following a 2 hour fast or following standard meal. After a 5 to 7 day washout period, subjects will receive the identical treatment in the alternate fed or fasted state. Plasma concentrations of 5-FU, 776C85 and uracil will be determined following drug administration on each occasion.
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