CRH STIMULATION W/WO DEXAMETHASONE IN DIAGNOSIS OF CUSHINGS SYNDROME

该方案涉及促肾上腺皮质激素释放激素(CRH)的使用 使用地塞米松和不使用地塞米松进行区分 一名患者患有库欣综合征和假性库欣综合征。 在提出这项建议时，CRH仍被归类为 研究药物，因此，只能在批准的 富有同情心地使用礼仪。 DJ有库欣综合征的病史，有过脑下垂体手术的前科。 由于她潜在的抑郁症和可能的美沙酮干扰 ACTH分泌，尚不清楚她的库欣病是否复发。 按照前面文献中所描述的那样，进行“Dex-CRH”测试 来自美国国立卫生研究院的研究人员对此进行了评估。血液和尿液测试 都做了手术，发现她的库欣病复发了。

This proposal involves the use of corticotrophin releasing hormone (CRH) both with and without dexamethasone for the purposes of distinguishing between Cushing's syndrome and pseudo-Cushing's in one patient. At the time of this proposal CRH was still classified as an investigational drug and, thus, could only be used under an approved compassionate use protocol. D.J. had a history of Cushing's syndrome with prior pituitary surgery. Due to her underlying depression and possible methadone interference with ACTH secretion, it was not clear whether her Cushing's had recurred. The "Dex-CRH" test was performed as previously described in the literature from researchers at the NIH to assess for this. Blood and urine tests were performed and revealed that her Cushing's had recurred.