Diversity and virulence determinants among 1000 clinical and environmental isolates of Burkholderia pseudomallei

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Melioidosis is an important infection in tropical northern Australia. It is a common cause of fatal pneumonia and blood infection in the region. Melioidosis results from infection with a soil bacterium. This project builds on the existing melioidosis collaboration between researchers in northern Australia and overseas to determine how the melioidosis bacterium can be so virulent and whether only a subset of the melioidosis bacteria found in the environment are capable of infecting humans.