Dnmt3L haploinsufficent retrotransposition leads to genetic hypermutation

Dnmt3L 单倍体不足的逆转录转座导致遗传超突变

• 批准号: nhmrc : 1011334
• 负责人: Prof David Adelson
• 金额: $ 40.94万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dnmt3l-haploinsufficent-retrotransposition-genetic-hypermutation/109575
• 关键词: Dnmt3L; haploinsufficent; retrotransposition; leads; genetic

This project aims to demonstrate the critical importance of DNA methylation as a cause of mutation and thus genetic diseases, many instances of sterility and low fertility, and cancers. Because DNA methylation can be partially determined by substrate availability, a demonstration of the importance of DNA methylation vis a vis mutation rates will refine our understanding of the impact of metabolism and nutrition on mutation rate as a cause of human disease.

该项目旨在证明DNA甲基化作为突变的原因以及遗传疾病，许多不育和低生育率以及癌症的重要性。由于DNA甲基化可以部分地由底物的可用性决定，因此DNA甲基化维斯维斯突变率的重要性的证明将完善我们对代谢和营养对突变率的影响作为人类疾病原因的理解。