Finding the targets of natural products in complex botanical extracts.

许多植物被用于营养和传统医学目的，并已显示出基于证据的效果。然而，确定导致所观察到的效应的单一化合物的标准方法失败了，因为它们依赖于具有单一靶标的单一化合物，而忽略了许多相互作用的化合物对许多靶标的总体效应。在本应用中，我们提出了一种新方法，可以同时识别复杂植物提取物中许多化合物的分子靶点，并通过基因表达对植物提取物的响应进行后续验证。这项研究将彻底改变人们对植物营养和药用作用的认识，并将使我们的合作伙伴加速商业化。

Many plants are used for nutritional and traditional medicine purposes and have demonstrated, evidence based effects. However, standard methods to identify single chemical compounds responsible for the observed effects fail as they rely on a single compound having a single target and ignore the overall effects of many interacting compounds on many targets. In this application we propose a new method to simultaneously identify the molecular targets of many compounds in complex plant extracts, along with their subsequent validation by responses in gene expression to the plant extract. This research will revolutionise understanding of the nutritional and medicinal effects of plants and will allow our partners to accelerate commercialisation.