Finding the targets of natural products in complex botanical extracts.

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Many plants are used for nutritional and traditional medicine purposes and have demonstrated, evidence based effects. However, standard methods to identify single chemical compounds responsible for the observed effects fail as they rely on a single compound having a single target and ignore the overall effects of many interacting compounds on many targets. In this application we propose a new method to simultaneously identify the molecular targets of many compounds in complex plant extracts, along with their subsequent validation by responses in gene expression to the plant extract. This research will revolutionise understanding of the nutritional and medicinal effects of plants and will allow our partners to accelerate commercialisation.