METABOLISM OF NON ESSENTIAL AMINO ACIDS IN HUMAN PREGNANCY

人类怀孕期间非必需氨基酸的代谢

• 批准号: 6276483
• 负责人: SATISH C KALHAN
• 金额: $ 1.83万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6276483
• 关键词: aminoacid metabolism; chemical kinetics; clinical research; diet therapy; embryo /fetus; female; gestational age; glycine; human pregnant subject; human subject; insulin dependent diabetes mellitus; mother /embryo /fetus nutrition; nitrogen metabolism; nutrition related tag; pregnancy; prenatal growth disorder; serine; urea; women's health

The proposed studies will quantify the kinetics and metabolism of serine during human pregnancy and examine its possible relation to fetal growth by examining such populations with fetal macrosomia and intrauterine growth retardation. It is hypothesized that as gestation advances and as the rates of urea synthesis decline, a significant change in the intrahepatic nitrogen metabolism occurs wherein increased amounts of nitrogen from ureagenic precursors are transferred to synthesize non- essential amino acids such as serine and glycine, and that glucose is a major source of serine carbon. It is further hypothesized that significant amounts of serine and glycine may be transferred to the fetus. Diabetes in pregnancy is characterized by increased protein breakdown, and thus it is expected that there is an increased rate of serine and glycine turnover. The plan of investigation continues to be to study normal pregnant women, pregnant women with insulin dependent diabetes, pregnant women with IUGR fetuses, women undergoing scheduled cesarean sections and non-pregnant controls. The normal pregnant women will be studied serially through pregnancy.

拟议的研究将量化丝氨酸的动力学和代谢 并研究其与胎儿生长的可能关系 通过检查这些人群中的巨大胎儿和宫内 生长迟缓 据推测，随着妊娠的进展， 随着尿素合成速率的下降， 发生肝内氮代谢，其中增加量的 尿素前体中的氮被转移到合成非- 必需氨基酸如丝氨酸和甘氨酸，并且葡萄糖是 丝氨酸碳的主要来源。 进一步假设， 显著量的丝氨酸和甘氨酸可以转移到 胎儿 妊娠期糖尿病的特征是蛋白质分解增加， 因此预期丝氨酸的比率增加， 甘氨酸周转率 调查计划继续研究 正常孕妇，胰岛素依赖型糖尿病孕妇， 胎儿宫内发育迟缓的孕妇，接受计划剖宫产的妇女 切片和非妊娠对照。正常的孕妇 在怀孕期间连续研究。