PLAAMA OXYCODONE CONCENTRATIONS IN CHILDREN

疼痛的充分治疗仍然是一个重大挑战， 临床医生 疼痛管理的相对不足已经很好地 记录门诊和住院儿科患者， 尽管有大量有效的阿片类和非阿片类药物， 临床使用的止痛药。 羟考酮是一种半合成 纯阿片类激动剂，性质类似于吗啡。 已经 用于治疗成人中度至中度重度疼痛 患者 本研究的目的是比较 羟考酮吸收和相关药代动力学参数 给儿童施用单剂量速释 羟考酮和控释羟考酮。 10名受试者 注册至今。

The adequate treatment of pain continues to be a mjor challenge for clinicians. The relative inadequacy of pain management has been well documented for ambulatory and hospitalized pediatric patients and persists despite the large number of effective opioid and non-opiate analgesics available for clinical use. Oxycodone is a semi-synthetic, pure opioid agonist with properties similar to morphine. It has been used for the treatment of moderate to moderately severe pain in adult patients. The objective of this study is to compare the extent of oxycodone absorption and related pharmacokinetic paramenters after the administration to children of a single dose of immediate-release oxycodone and controlled-release oxycodone. Ten subjects have been enrolled to date.