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NATURAL HISTORY OF ANAL NEOPLASIA--ACTG 216

NATURAL HISTORY OF ANAL NEOPLASIA--ACTG 216
肛门肿瘤的自然史--ACTG 216
批准号：
6276449
负责人：
JOEL Michael PALEFSKY
金额：
$6.43万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6276449
关键词：
13 cis retinoate HIV infections cancer prevention cancer risk chemoprevention clinical research combination cancer therapy dosage drug screening /evaluation gastrointestinal epithelium histopathology homosexuals human subject human therapy evaluation interferon alpha male neoplasm /cancer chemotherapy neoplasm /cancer relapse /recurrence neoplasm /cancer surgery neoplastic process preneoplastic state rectum neoplasms virus related neoplasm /cancer

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中文摘要
翻译
目的是研究hiv阳性和阴性同性恋男性肛门上皮癌前细胞学和组织病理学改变的发生和进展，确定危险因素，进行异维a酸和干扰素- α的剂量升级研究，确定(1)单独消融，(2)异维a酸联合消融，(3)异维a酸和干扰素- α联合消融预防复发的疗效。
英文摘要
Goals are to study the development and progression of precancerous cytologic and histo-pathologic changes of the anal epithelium among HIV-positive and negative homosexual men, to identify risk factors, perform dose escalation studies of isotretinoin and interferon-alpha, determine efficacy of prevention recurrence by (1)ablation alone, (2) ablation in combination with isotretinoin, and (3) ablation in combination with isotretinoin and interferon-alpha.
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